RRC ID |
34434
|
Author |
Komura M, Fukuta T, Genda T, Hino S, Aoe S, Kawagishi H, Morita T.
|
Title |
A short-term ingestion of fructo-oligosaccharides increases immunoglobulin A and mucin concentrations in the rat cecum, but the effects are attenuated with the prolonged ingestion.
|
Journal |
Biosci Biotechnol Biochem
|
Abstract |
We examined the effects of fructo-oligosaccharides (FOS) on IgA and mucin secretion in the rat cecum after different ingestion periods. Rats were fed a control diet or a diet containing FOS for 1, 2, 4, and 8 wk. FOS ingestion greatly increased IgA and mucin concentrations at 1 and 2 wk, but the effects were disappeared or attenuated at 4 and 8 wk. After 1 wk, FOS induced higher lactobacilli and lactate concentrations and lower cecal pH in the cecum, but the alterations were moderated with the prolonged ingestion accompanying with increasing short-chain fatty acid concentrations. At 1 and 2 wk, FOS increased IgA plasma cells and polymeric immunoglobulin receptor expression in the cecal mucosa and strongly depressed fecal mucinase activities related to the lower cecal pH. These findings may explain the FOS-induced early elevation of IgA and mucin. Clearly, FOS effects on IgA and mucin secretion considerably differ depending on the ingestion period.
|
Volume |
78(9)
|
Pages |
1592-602
|
Published |
2014-1-1
|
DOI |
10.1080/09168451.2014.925782
|
PMID |
25209509
|
MeSH |
Animals
Cecum / enzymology
Cecum / metabolism*
Diet
Eating
Fatty Acids, Volatile
Feces
Humans
Immunoglobulin A / biosynthesis*
Immunoglobulin A / metabolism
Lactic Acid / metabolism
Lactobacillus
Mucins / biosynthesis*
Mucins / metabolism
Oligosaccharides / administration & dosage*
Polysaccharide-Lyases / metabolism
Rats
|
IF |
1.516
|
Times Cited |
11
|
WOS Category
|
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
CHEMISTRY, APPLIED
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
Resource |
General Microbes |
JCM 1190
JCM 1717 |