論文 - 詳細
| RRC ID | 34466 |
|---|---|
| 著者 | Kasakura K, Takahashi K, Itoh T, Hosono A, Momose Y, Itoh K, Nishiyama C, Kaminogawa S. |
| タイトル | Commensal bacteria directly suppress in vitro degranulation of mast cells in a MyD88-independent manner. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
The intestine harbors a substantial number of commensal bacteria that provide considerable benefits to the host. Epidemiologic studies have identified associations between alterations in the composition of the intestinal microbiota and the development of allergic disease. However, the cellular and molecular mechanisms underlying these effects remain to be determined. Here, we show that heat-killed commensal bacteria suppressed degranulation of mast cells in vitro in a MyD88-independent manner. In particular, Enterococcus faecalis showed the strongest suppression of degranulation through partial inhibition of Ca(2+) signaling upon the high affinity IgE receptor (FcεRI) cross-linking. |
| 巻・号 | 78(10) |
| ページ | 1669-76 |
| 公開日 | 2014-1-1 |
| DOI | 10.1080/09168451.2014.930327 |
| PMID | 25273132 |
| MeSH | Animals Cell Degranulation* Enterococcus faecalis / physiology* Female Intracellular Space / metabolism Mast Cells / cytology* Mice Myeloid Differentiation Factor 88 / metabolism* Signal Transduction |
| IF | 1.516 |
| 引用数 | 11 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1649 JCM 5824 JCM 5826 JCM 5827 |