論文 - 詳細
| RRC ID | 34477 |
|---|---|
| 著者 | Mao B, Li D, Zhao J, Liu X, Gu Z, Chen YQ, Zhang H, Chen W. |
| タイトル | In vitro fermentation of lactulose by human gut bacteria. |
| ジャーナル | J Agric Food Chem |
| Abstract |
Lactulose has been known as a prebiotic that can selectively stimulate the growth of beneficial bifidobacteria and lactobacilli. Recent studies have indicated that Streptococcus mutans, Clostridium perfringens, and Faecalibacterium prausnitzii are also able to utilize lactulose. However, the previous studies mainly focused on the utilization of lactulose by individual strains, and few studies were designed to identify the species that could utilize lactulose among gut microbiota. This study aimed to identify lactulose-metabolizing bacteria in the human gut, using in silico and traditional culture methods. The prediction results suggested that genes for the transporters and glycosidases of lactulose are well distributed in the genomes of 222 of 453 strains of gastrointestinal-tract bacteria. The screening assays identified 35 species with the ability to utilize lactulose, of which Cronobacter sakazakii, Enterococcus faecium, Klebsiella pneumoniae, and Pseudomonas putida were reported for the first time to be capable of utilizing lactulose. In addition, significant correlations between lactulose and galactooligosaccharide metabolism were found. Thus, more attention should be paid to bacteria besides bifidobacteria and lactobacilli to further investigate the relationship between functional oligosaccharides and gut bacteria. |
| 巻・号 | 62(45) |
| ページ | 10970-7 |
| 公開日 | 2014-11-12 |
| DOI | 10.1021/jf503484d |
| PMID | 25340538 |
| MeSH | Bacteria / classification Bacteria / genetics Bacteria / isolation & purification Bacteria / metabolism* Feces / microbiology Fermentation Gastrointestinal Tract / microbiology* Humans Lactulose / metabolism* Molecular Sequence Data Phylogeny |
| IF | 4.192 |
| 引用数 | 24 |
| WOS 分野 | AGRICULTURE, MULTIDISCIPLINARY FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 14723 |