Reference - Detail
| RRC ID | 34543 |
|---|---|
| Author | Nishimura T, Sato T, Yamamoto Y, Watakabe I, Ohkawa Y, Suyama M, Kobayashi S, Tanaka M. |
| Title | Sex determination. foxl3 is a germ cell-intrinsic factor involved in sperm-egg fate decision in medaka. |
| Journal | Science |
| Abstract |
Sex determination is an essential step in the commitment of a germ cell to a sperm or egg. However, the intrinsic factors that determine the sexual fate of vertebrate germ cells are unknown. Here, we show that foxl3, which is expressed in germ cells but not somatic cells in the gonad, is involved in sperm-egg fate decision in medaka fish. Adult XX medaka with disrupted foxl3 developed functional sperm in the expanded germinal epithelium of a histologically functional ovary. In chimeric medaka, mutant germ cells initiated spermatogenesis in female wild-type gonad. These results indicate that a germ cell-intrinsic cue for the sperm-egg fate decision is present in medaka and that spermatogenesis can proceed in a female gonadal environment. |
| Volume | 349(6245) |
| Pages | 328-31 |
| Published | 2015-7-17 |
| DOI | 10.1126/science.aaa2657 |
| PII | science.aaa2657 |
| PMID | 26067255 |
| MeSH | Animals Female Forkhead Transcription Factors / genetics Forkhead Transcription Factors / physiology* Male Oocytes / cytology Oocytes / physiology* Oryzias / genetics Oryzias / growth & development* Sex Determination Processes / genetics* Spermatogenesis / genetics Spermatozoa / cytology Spermatozoa / physiology* |
| IF | 41.846 |
| Times Cited | 52 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 81 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Medaka | cDNAs BAC and fosmids clones |