RRC ID 34650
Author Nagai T, Taya K, Yoda I.
Title Comparative toxicity of 20 herbicides to 5 periphytic algae and the relationship with mode of action.
Journal Environ Toxicol Chem
Abstract The authors used 5 species of periphytic algae to conduct toxicity assays of 20 herbicides. The 5 tested species represent riverine primary producers most likely to be affected by herbicides. A fluorescence microplate toxicity assay was used as an efficient and economical high-throughput assay. Toxicity characteristics were analyzed, focusing on their relationship to herbicide mode of action. The relative differences between 50% and 10% effect concentrations depended on herbicide mode of action, rather than tested species. Moreover, a clear relationship between sensitive species and herbicide mode of action was also observed. Green alga was most sensitive to herbicides of 2 mode of action groups: inhibitors of protoporphyrinogen oxidase and very long-chain fatty acid synthesis. Diatoms were most sensitive to herbicides of 1 mode of action group: 4-hydroxyphenyl-pyruvate-dioxygenase inhibitors. Cyanobacterium was most sensitive to herbicides of 1 mode of action group: inhibitors of acetolactate synthase. The species sensitivity distribution based on obtained data was also analyzed. The slopes of the species sensitivity distribution significantly differed among modes of action, suggesting that difference in species sensitivity is specific to the mode of action. In particular, differences in species sensitivity were markedly large for inhibitors of acetolactate synthase, protoporphyrinogen oxidase, and very long-chain fatty acid synthesis. The results clearly showed that a single algal species cannot represent the sensitivity of an algal assemblage. Therefore, multispecies algal toxicity data are essential for substances with specific modes of action.
Volume 35(2)
Pages 368-75
Published 2016-2-1
DOI 10.1002/etc.3150
PMID 26174500
MeSH 4-Hydroxyphenylpyruvate Dioxygenase / antagonists & inhibitors Acetolactate Synthase / antagonists & inhibitors Chlorophyta / drug effects* Cyanobacteria / drug effects* Diatoms / drug effects* Enzyme Inhibitors / toxicity Fatty Acid Synthases / antagonists & inhibitors Fatty Acid Synthases / metabolism Herbicides / analysis Herbicides / chemistry Herbicides / toxicity* Japan Protoporphyrinogen Oxidase / antagonists & inhibitors Protoporphyrinogen Oxidase / metabolism Reproducibility of Results Solubility Species Specificity Water Pollutants, Chemical / analysis Water Pollutants, Chemical / chemistry Water Pollutants, Chemical / toxicity*
IF 3.152
Times Cited 15
Algae NIES-512 NIES-797 NIES-71 NIES-487