| RRC ID |
34752
|
| Author |
Jiang HC, Hsu JM, Yen CP, Chao CC, Chen RH, Pan CL.
|
| Title |
Neural activity and CaMKII protect mitochondria from fragmentation in aging Caenorhabditis elegans neurons.
|
| Journal |
Proc Natl Acad Sci U S A
|
| Abstract |
Decline in mitochondrial morphology and function is a hallmark of neuronal aging. Here we report that progressive mitochondrial fragmentation is a common manifestation of aging Caenorhabditis elegans neurons and body wall muscles. We show that sensory-evoked activity was essential for maintaining neuronal mitochondrial morphology, and this activity-dependent mechanism required the Degenerin/ENaC sodium channel MEC-4, the L-type voltage-gated calcium channel EGL-19, and the Ca/calmodulin-dependent kinase II (CaMKII) UNC-43. Importantly, UNC-43 phosphorylated and inhibited the dynamin-related protein (DRP)-1, which was responsible for excessive mitochondrial fragmentation in neurons that lacked sensory-evoked activity. Moreover, enhanced activity in the aged neurons ameliorated mitochondrial fragmentation. These findings provide a detailed description of mitochondrial behavior in aging neurons and identify activity-dependent DRP-1 phosphorylation by CaMKII as a key mechanism in neuronal mitochondrial maintenance.
|
| Volume |
112(28)
|
| Pages |
8768-73
|
| Published |
2015-7-14
|
| DOI |
10.1073/pnas.1501831112
|
| PII |
1501831112
|
| PMID |
26124107
|
| PMC |
PMC4507213
|
| MeSH |
Aging
Animals
Caenorhabditis elegans / enzymology
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins / physiology
Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism*
Longevity
Mitochondria / physiology*
Neurons / enzymology
Neurons / physiology*
Oxidation-Reduction
|
| IF |
9.412
|
| Times Cited |
20
|
|
WOS Category
|
MULTIDISCIPLINARY SCIENCES
|
| Resource |
| C.elegans |
fzo-1(tm1133)
drp-1(tm1108) |
