論文 - 詳細
| RRC ID | 34752 |
|---|---|
| 著者 | Jiang HC, Hsu JM, Yen CP, Chao CC, Chen RH, Pan CL. |
| タイトル | Neural activity and CaMKII protect mitochondria from fragmentation in aging Caenorhabditis elegans neurons. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Decline in mitochondrial morphology and function is a hallmark of neuronal aging. Here we report that progressive mitochondrial fragmentation is a common manifestation of aging Caenorhabditis elegans neurons and body wall muscles. We show that sensory-evoked activity was essential for maintaining neuronal mitochondrial morphology, and this activity-dependent mechanism required the Degenerin/ENaC sodium channel MEC-4, the L-type voltage-gated calcium channel EGL-19, and the Ca/calmodulin-dependent kinase II (CaMKII) UNC-43. Importantly, UNC-43 phosphorylated and inhibited the dynamin-related protein (DRP)-1, which was responsible for excessive mitochondrial fragmentation in neurons that lacked sensory-evoked activity. Moreover, enhanced activity in the aged neurons ameliorated mitochondrial fragmentation. These findings provide a detailed description of mitochondrial behavior in aging neurons and identify activity-dependent DRP-1 phosphorylation by CaMKII as a key mechanism in neuronal mitochondrial maintenance. |
| 巻・号 | 112(28) |
| ページ | 8768-73 |
| 公開日 | 2015-7-14 |
| DOI | 10.1073/pnas.1501831112 |
| PII | 1501831112 |
| PMID | 26124107 |
| PMC | PMC4507213 |
| MeSH | Aging Animals Caenorhabditis elegans / enzymology Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / physiology Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism* Longevity Mitochondria / physiology* Neurons / enzymology Neurons / physiology* Oxidation-Reduction |
| IF | 9.412 |
| 引用数 | 20 |
| WOS 分野 | MULTIDISCIPLINARY SCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | fzo-1(tm1133) drp-1(tm1108) |