論文 - 詳細
| RRC ID | 34799 |
|---|---|
| 著者 | Harper NC, Rillo R, Jover-Gil S, Assaf ZJ, Bhalla N, Dernburg AF. |
| タイトル | Pairing centers recruit a Polo-like kinase to orchestrate meiotic chromosome dynamics in C. elegans. |
| ジャーナル | Dev Cell |
| Abstract |
Faithful segregation of homologous chromosomes during meiosis requires pairing, synapsis, and crossing-over. In C. elegans, homolog pairing and synapsis depend on pairing centers (PCs), special regions near one end of each chromosome that interact with the nuclear envelope (NE) and cytoplasmic microtubules. Here, we report that PCs are required for nuclear reorganization at the onset of meiosis. We demonstrate that PCs recruit the Polo-like kinase PLK-2 to induce NE remodeling, chromosome pairing, and synapsis. Recruitment of PLK-2 is also required to mediate a cell cycle delay and selective apoptosis of nuclei containing unsynapsed chromosomes, establishing a molecular link between these two quality control mechanisms. This work reveals unexpected functions for the conserved family of Polo-like kinases, and advances our understanding of how meiotic processes are properly coordinated to ensure transmission of genetic information from parents to progeny. |
| 巻・号 | 21(5) |
| ページ | 934-47 |
| 公開日 | 2011-11-15 |
| DOI | 10.1016/j.devcel.2011.09.001 |
| PII | S1534-5807(11)00399-6 |
| PMID | 22018922 |
| PMC | PMC4343031 |
| MeSH | Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Chromosome Pairing / genetics* Meiosis / genetics* Nuclear Envelope / genetics Nuclear Envelope / metabolism Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism* |
| IF | 10.092 |
| 引用数 | 59 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 線虫 | plk-2(tm1395) tm611 |