論文 - 詳細
| RRC ID | 34830 |
|---|---|
| 著者 | Tsuyama J, Bunt J, Richards LJ, Iwanari H, Mochizuki Y, Hamakubo T, Shimazaki T, Okano H. |
| タイトル | MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells. |
| ジャーナル | Stem Cell Reports |
| Abstract |
Mammalian neural stem/progenitor cells (NSPCs) sequentially generate neurons and glia during CNS development. Here we identified miRNA-153 (miR-153) as a modulator of the temporal regulation of NSPC differentiation. Overexpression (OE) of miR-153 delayed the onset of astrogliogenesis and maintained NSPCs in an undifferentiated state in vitro and in the developing cortex. The transcription factors nuclear factor I (NFI) A and B, essential regulators of the initiation of gliogenesis, were found to be targets of miR-153. Inhibition of miR-153 in early neurogenic NSPCs induced precocious gliogenesis, whereas NFIA/B overexpression rescued the anti-gliogenic phenotypes induced by miR-153 OE. Our results indicate that miR-mediated fine control of NFIA/B expression is important in the molecular networks that regulate the acquisition of gliogenic competence by NSPCs in the developing CNS. |
| 巻・号 | 5(3) |
| ページ | 365-77 |
| 公開日 | 2015-9-8 |
| DOI | 10.1016/j.stemcr.2015.06.006 |
| PII | S2213-6711(15)00187-3 |
| PMID | 26212661 |
| PMC | PMC4618452 |
| MeSH | Animals Cell Differentiation / physiology* Cerebral Cortex / cytology Cerebral Cortex / metabolism* Mice MicroRNAs / genetics MicroRNAs / metabolism* NFI Transcription Factors / genetics NFI Transcription Factors / metabolism Neural Stem Cells / cytology Neural Stem Cells / metabolism* Neuroglia / cytology Neuroglia / metabolism* |
| IF | 6.032 |
| 引用数 | 22 |
| WOS 分野 | CELL & TISSUE ENGINEERING CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | pCAGGS-LIF (RDB09182) pCAG-HIVgp (RDB04394) pCMV-VSV-G-RSV-Rev (RDB04393) |