Reference - Detail
| RRC ID | 34869 |
|---|---|
| Author | Morán T, Bernués J, Azorín F. |
| Title | The Drosophila histone demethylase dKDM5/LID regulates hematopoietic development. |
| Journal | Dev Biol |
| Abstract |
dKDM5/LID regulates transcription of essential developmental genes and, thus, is required for different developmental processes. Here, we report the essential contribution of dKDM5/LID to hematopoiesis in Drosophila. Our results show that dKDM5/LID is abundant in hemocytes and that its depletion induces over-proliferation and differentiation defects of larval hemocytes and disrupts organization of the actin cytoskeleton. We also show that dKDM5/LID regulates expression of key factors of hematopoietic development. In particular, dKDM5/LID depletion up-regulates expression of several transcription factors involved in hemocytes proliferation and differentiation as well as of several small-GTPases that link signaling effectors to actin cytoskeleton formation and dynamics. |
| Volume | 405(2) |
| Pages | 260-8 |
| Published | 2015-9-15 |
| DOI | 10.1016/j.ydbio.2015.07.011 |
| PII | S0012-1606(15)30053-1 |
| PMID | 26183107 |
| MeSH | Actins / metabolism Animals Animals, Genetically Modified Cell Differentiation Cell Movement Cell Proliferation Cytoskeleton / metabolism Drosophila / embryology Drosophila / enzymology* Drosophila Proteins / physiology* Female Gene Expression Regulation, Developmental* Hematopoiesis / genetics* Hemocytes / cytology Hemocytes / metabolism Histone Demethylases / physiology* Immunohistochemistry Larva / enzymology Male Transcription Factors / metabolism Transcription, Genetic |
| IF | 2.896 |
| Times Cited | 4 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Resource | |
| Drosophila | 9088R-1 9088R-2 GFP-IR-1 |