論文 - 詳細
| RRC ID | 34892 |
|---|---|
| 著者 | Huang J, Xue L. |
| タイトル | Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila. |
| ジャーナル | Biomed Res Int |
| Abstract |
falafel (flfl) encodes a Drosophila homolog of human SMEK whose in vivo functions remain elusive. In this study, we performed gain-of-function and loss-of-function analysis in Drosophila and identified flfl as a negative regulator of JNK pathway-mediated cell death. While ectopic expression of flfl suppresses TNF-triggered JNK-dependent cell death, loss of flfl promotes JNK activation and cell death in the developing eye and wing. These data report for the first time an essential physiological function of flfl in maintaining tissue homeostasis and organ development. As the JNK signaling pathway has been evolutionary conserved from fly to human, a similar role of PP4R3 in JNK-mediated physiological process is speculated. |
| 巻・号 | 2015 |
| ページ | 623573 |
| 公開日 | 2015-10-25 |
| DOI | 10.1155/2015/623573 |
| PMID | 26583122 |
| PMC | PMC4637051 |
| MeSH | Animals Animals, Genetically Modified Apoptosis / genetics* Drosophila Proteins Drosophila melanogaster / genetics* Eye / growth & development Gene Expression Regulation, Developmental Humans MAP Kinase Signaling System / genetics* Phosphoprotein Phosphatases / genetics* Signal Transduction / genetics Wings, Animal / growth & development |
| IF | 2.276 |
| 引用数 | 6 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 5680R-2 |