論文 - 詳細
| RRC ID | 35148 |
|---|---|
| 著者 | Waki K, Imai KS, Satou Y. |
| タイトル | Genetic pathways for differentiation of the peripheral nervous system in ascidians. |
| ジャーナル | Nat Commun |
| Abstract |
Ascidians belong to tunicates, the sister group of vertebrates. Peripheral nervous systems (PNSs) including epidermal sensory neurons (ESNs) in the trunk and dorsal tail regions of ascidian larvae are derived from cells adjacent to the neural plate, as in vertebrates. On the other hand, peripheral ESNs in the ventral tail region are derived from the ventral ectoderm under the control of BMP signalling, reminiscent of sensory neurons of amphioxus and protostomes. In this study, we show that two distinct mechanisms activate a common gene circuit consisting of Msx, Ascl.b, Tox, Delta.b and Pou4 in the dorsal and ventral regions to differentiate ESNs. Our results suggest that ventral ESNs of the ascidian larva are not directly homologous to vertebrate PNSs. The dorsal ESNs might have arisen via co-option of the original PNS gene circuit to the neural plate border in an ancestral chordate. |
| 巻・号 | 6 |
| ページ | 8719 |
| 公開日 | 2015-10-30 |
| DOI | 10.1038/ncomms9719 |
| PII | ncomms9719 |
| PMID | 26515371 |
| PMC | PMC4640076 |
| MeSH | Animals Cell Differentiation Gene Expression Regulation, Developmental Peripheral Nervous System / cytology Peripheral Nervous System / metabolism Proteins / genetics Proteins / metabolism Sensory Receptor Cells / cytology Sensory Receptor Cells / metabolism Urochordata / cytology Urochordata / genetics* Urochordata / growth & development* Urochordata / metabolism |
| IF | 12.121 |
| 引用数 | 15 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| カタユウレイボヤ・(ニッポンウミシダ) | Wild C. int |