| RRC ID |
35169
|
| 著者 |
Tada H, Kuroki Y, Funabashi T, Kamiya Y, Goto T, Suyama K, Sano A, Mitsushima D, Etgen AM, Takahashi T.
|
| タイトル |
Phasic synaptic incorporation of GluR2-lacking AMPA receptors at gonadotropin-releasing hormone neurons is involved in the generation of the luteinizing hormone surge in female rats.
|
| ジャーナル |
Neuroscience
|
| Abstract |
Reproductive success depends on a robust and appropriately timed preovulatory luteinizing hormone (LH) surge, which is induced by the activation of gonadotropin-releasing hormone (GnRH) neurons in response to positive feedback from increasing estrogen levels. Here we document an increase in postsynaptic GluR2-lacking Ca2+ -permeable AMPA-type glutamate receptors (CP-AMPARs) at synapses on GnRH neurons on the day of proestrus in rats, coincident with the increase in estrogen levels. Functional blockade of CP-AMPARs depressed the synaptic responses only on the day of proestrus and concomitantly attenuated the LH surge. Thus, the phasic synaptic incorporation of postsynaptic CP-AMPARs on GnRH neurons is involved in the generation of the LH surge.
|
| 巻・号 |
248
|
| ページ |
664-9
|
| 公開日 |
2013-9-17
|
| DOI |
10.1016/j.neuroscience.2013.06.040
|
| PII |
S0306-4522(13)00546-0
|
| PMID |
23811398
|
| MeSH |
Animals
Estrogens / physiology
Female
Gonadotropin-Releasing Hormone / metabolism*
In Vitro Techniques
Luteinizing Hormone / blood*
Neurons / physiology
Rats
Rats, Wistar
Receptors, AMPA / physiology*
Reproduction
Synapses / physiology*
|
| IF |
3.056
|
| 引用数 |
13
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| ラット |
W-Tg(Gnrh1-EGFP)Nphy |
