| RRC ID |
3522
|
| Author |
Meier B, Clejan I, Liu Y, Lowden M, Gartner A, Hodgkin J, Ahmed S.
|
| Title |
trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase.
|
| Journal |
PLoS Genet
|
| Abstract |
Mutants of trt-1, the Caenorhabditis elegans telomerase reverse transcriptase, reproduce normally for several generations but eventually become sterile as a consequence of telomere erosion and end-to-end chromosome fusions. Telomere erosion and uncapping do not cause an increase in apoptosis in the germlines of trt-1 mutants. Instead, late-generation trt-1 mutants display chromosome segregation defects that are likely to be the direct cause of sterility. trt-1 functions in the same telomere replication pathway as mrt-2, a component of the Rad9/Rad1/Hus1 (9-1-1) proliferating cell nuclear antigen-like sliding clamp. Thus, the 9-1-1 complex may be required for telomerase to act at chromosome ends in C. elegans. Although telomere erosion limits replicative life span in human somatic cells, neither trt-1 nor telomere shortening affects postmitotic aging in C. elegans. These findings illustrate effects of telomere dysfunction in C. elegans mutants lacking the catalytic subunit of telomerase, trt-1.
|
| Volume |
2(2)
|
| Pages |
e18
|
| Published |
2006-2-1
|
| DOI |
10.1371/journal.pgen.0020018
|
| PMID |
16477310
|
| PMC |
PMC1361356
|
| MeSH |
Animals
Apoptosis
Caenorhabditis elegans
Caenorhabditis elegans Proteins / physiology
Catalysis
Catalytic Domain
DNA Replication
DNA-Binding Proteins / genetics*
Genes, Helminth
Germ-Line Mutation
Mitosis
Mutation*
Telomerase / genetics*
Telomere / ultrastructure*
|
| IF |
5.175
|
| Times Cited |
61
|
|
WOS Category
|
GENETICS & HEREDITY
|
| Resource |
| C.elegans |
tm899 |
