論文 - 詳細
| RRC ID | 3548 |
|---|---|
| 著者 | Squirrell JM, Eggers ZT, Luedke N, Saari B, Grimson A, Lyons GE, Anderson P, White JG. |
| タイトル | CAR-1, a protein that localizes with the mRNA decapping component DCAP-1, is required for cytokinesis and ER organization in Caenorhabditis elegans embryos. |
| ジャーナル | Mol Biol Cell |
| Abstract |
The division of one cell into two requires the coordination of multiple components. We describe a gene, car-1, whose product may provide a link between disparate cellular processes. Inhibition of car-1 expression in Caenorhabditis elegans embryos causes late cytokinesis failures: cleavage furrows ingress but subsequently regress and the spindle midzone fails to form, even though midzone components are present. The localized accumulation of membrane that normally develops at the apex of the cleavage furrow during the final phase of cytokinesis does not occur and organization of the endoplasmic reticulum is aberrant, indicative of a disruption in membrane trafficking. The car-1 gene has homologues in a number of species, including proteins that associate with RNA binding proteins. CAR-1 localizes to P-granules (germ-line specific ribonucleoprotein particles) and discrete, developmentally regulated cytoplasmic foci. These foci also contain DCAP-1, a protein involved in decapping mRNAs. Thus, CAR-1, a protein likely to be associated with RNA metabolism, plays an essential role in the late stage of cytokinesis, suggesting a novel link between RNA, membrane trafficking and cytokinesis in the C. elegans embryo. |
| 巻・号 | 17(1) |
| ページ | 336-44 |
| 公開日 | 2006-1-1 |
| DOI | 10.1091/mbc.e05-09-0874 |
| PII | E05-09-0874 |
| PMID | 16267265 |
| PMC | PMC1345671 |
| MeSH | Animals Caenorhabditis elegans / cytology* Caenorhabditis elegans / embryology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cytokinesis Cytoplasm / metabolism Embryo, Nonmammalian / cytology* Embryo, Nonmammalian / embryology Embryo, Nonmammalian / metabolism* Endoplasmic Reticulum / metabolism* Endoribonucleases / genetics Endoribonucleases / metabolism* Gene Expression Regulation Protein Transport RNA Caps / genetics RNA Caps / metabolism RNA Interference RNA-Binding Proteins / genetics RNA-Binding Proteins / metabolism* Time Factors |
| IF | 3.791 |
| 引用数 | 67 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1753 |