論文 - 詳細
| RRC ID | 3551 |
|---|---|
| 著者 | Tanizawa Y, Kuhara A, Inada H, Kodama E, Mizuno T, Mori I. |
| タイトル | Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans. |
| ジャーナル | Genes Dev |
| Abstract |
Although recent studies have provided significant molecular insights into the establishment of neuronal polarity in vitro, evidence is lacking on the corresponding phenomena in vivo, including correct localization of synaptic components and the importance of this process for function of the nervous system as a whole. RIA interneurons act as a pivotal component of the neural circuit for thermotaxis behavior in the nematode Caenorhabditis elegans and provide a suitable model to investigate these issues, having a neurite clearly divided into pre- and post-synaptic regions. In a screen for thermotaxis mutants, we identified the gene ttx-7, which encodes myo-inositol monophosphatase (IMPase), an inositol-producing enzyme regarded as a bipolar disorder-relevant molecule for its lithium sensitivity. Here we show that mutations in ttx-7 cause defects in thermotaxis behavior and localization of synaptic proteins in RIA neurons in vivo. Both behavioral and localization defects in ttx-7 mutants were rescued by expression of IMPase in adults and by inositol application, and the same defects were mimicked by lithium treatment in wild-type animals. These results suggest that IMPase is required in central interneurons of the mature nervous system for correct localization of synaptic components and thus for normal behavior. |
| 巻・号 | 20(23) |
| ページ | 3296-310 |
| 公開日 | 2006-12-1 |
| DOI | 10.1101/gad.1497806 |
| PII | 20/23/3296 |
| PMID | 17158747 |
| PMC | PMC1686606 |
| MeSH | Amino Acid Sequence Animals Caenorhabditis elegans / enzymology* Caenorhabditis elegans / growth & development Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Movement Conserved Sequence Interneurons / enzymology Interneurons / physiology* Molecular Sequence Data Nervous System Physiological Phenomena* Neurons / enzymology Neurons / physiology Phosphoric Monoester Hydrolases / chemistry Phosphoric Monoester Hydrolases / genetics Phosphoric Monoester Hydrolases / metabolism* Phylogeny Sequence Alignment Sequence Homology, Amino Acid Synapses / physiology* |
| IF | 9.527 |
| 引用数 | 53 |
| WOS 分野 | GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
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オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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| 線虫 | tm2223 |