論文 - 詳細
| RRC ID | 35591 |
|---|---|
| 著者 | Shimada T, Yamazaki K, Ishihama A. |
| タイトル | Novel regulator PgrR for switch control of peptidoglycan recycling in Escherichia coli. |
| ジャーナル | Genes Cells |
| Abstract |
Peptidoglycan (PG), also designated as murein, forms a skeletal mesh within the periplasm of bacterial membrane. PG is a metabolically stable cell architecture in Escherichia coli, but under as yet ill-defined conditions, a portion of PG is degraded, of which both amino sugar and peptide moieties are either recycled or used as self-generated nutrients for cell growth. At present, the control of PG degradation remains uncharacterized. Using the Genomic SELEX screening system, we identified an uncharacterized transcription factor YcjZ is a repressor of the expression of the initial step enzymes for PG peptide degradation. Under nutrient starvation, the genes encoding the enzymes for PG peptide degradation are derepressed so as to generate amino acids but are tightly repressed at high osmotic conditions so as to maintain the rigid membrane for withstanding the turgor. Taken together, we propose to rename YcjZ as PgrR (regulator of peptide glycan recycling). |
| 巻・号 | 18(2) |
| ページ | 123-34 |
| 公開日 | 2013-2-1 |
| DOI | 10.1111/gtc.12026 |
| PMID | 23301696 |
| MeSH | Base Sequence Binding Sites DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Escherichia coli / genetics Escherichia coli / metabolism* Escherichia coli Proteins / genetics Escherichia coli Proteins / metabolism* Gene Expression Regulation, Bacterial Genes, Reporter Nucleotide Motifs Operator Regions, Genetic Peptidoglycan / metabolism* Protein Binding Proteolysis Transcription Factors / genetics Transcription Factors / metabolism* Transcription, Genetic |
| IF | 1.655 |
| 引用数 | 11 |
| WOS 分野 | GENETICS & HEREDITY CELL BIOLOGY |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 原核生物(大腸菌) | JW1321-KC |