RRC ID 35596
Author Hase Y, Tarusawa T, Muto A, Himeno H.
Title Impairment of ribosome maturation or function confers salt resistance on Escherichia coli cells.
Journal PLoS One
Abstract We found that loss of integrity of the ribosome by removal of a putative ribosome maturation factor or a ribosomal protein conferred salt tolerance on Escherichia coli cells. Some protein synthesis inhibitors including kasugamycin and chloramphenicol also had a similar effect, although kasugamycin affected neither 16S rRNA maturation nor subunit association into a 70S ribosome. Thus, salt tolerance is a common feature of cells in which maturation or function of the ribosome is impaired. In these cells, premature induction of an alternative sigma factor, σ(E), by salt stress was observed. These results suggest the existence of a yet-unknown stress response pathway mediated by the bacterial ribosome.
Volume 8(5)
Pages e65747
Published 2013
DOI 10.1371/journal.pone.0065747
PII PONE-D-12-39672
PMID 23741511
PMC PMC3669203
MeSH Aminoglycosides / pharmacology Anti-Bacterial Agents / pharmacology DNA / biosynthesis DNA Replication / drug effects Escherichia coli / genetics* Escherichia coli / metabolism* Escherichia coli Proteins / genetics Gene Expression Regulation, Bacterial / drug effects Mutation RNA, Ribosomal, 16S / genetics RNA, Ribosomal, 16S / metabolism Ribosomes / metabolism* Salt Tolerance / genetics* Sigma Factor / metabolism Stress, Physiological / genetics
IF 2.776
Times Cited 7
WOS Category BIOCHEMISTRY & MOLECULAR BIOLOGY
Resource
Prokaryotes E. coli ME9062(BW25113)