論文 - 詳細
| RRC ID | 35682 |
|---|---|
| 著者 | Ishikawa R, Amano Y, Kawakami M, Sunohara M, Watanabe K, Kage H, Ohishi N, Yatomi Y, Nakajima J, Fukayama M, Nagase T, Takai D. |
| タイトル | The chimeric transcript RUNX1-GLRX5: a biomarker for good postoperative prognosis in Stage IA non-small-cell lung cancer. |
| ジャーナル | Jpn J Clin Oncol |
| Abstract |
Stage IA non-small-cell lung cancer cases have been recognized as having a low risk of relapse; however, occasionally, relapse may occur. To predict clinical outcome in Stage IA non-small-cell lung cancer patients, we searched for chimeric transcripts that can be used as biomarkers and identified a novel chimeric transcript, RUNX1-GLRX5, comprising RUNX1, a transcription factor, and GLRX5. This chimera was detected in approximately half of the investigated Stage IA non-small-cell lung cancer patients (44/104 cases, 42.3%). Although there was no significant difference in the overall survival rate between RUNX1-GLRX5-positive and -negative cases (P = 0.088), a significantly lower relapse rate was observed in the RUNX1-GLRX5-positive cases (P = 0.039), indicating that this chimera can be used as a biomarker for good prognosis in Stage IA patients. Detection of the RUNX1-GLRX5 chimeric transcript may therefore be useful for the determination of a postoperative treatment plan for Stage IA non-small-cell lung cancer patients. |
| 巻・号 | 46(2) |
| ページ | 185-9 |
| 公開日 | 2016-2-1 |
| DOI | 10.1093/jjco/hyv187 |
| PII | hyv187 |
| PMID | 26685324 |
| PMC | PMC4731000 |
| MeSH | Aged Biomarkers, Tumor / analysis* Carcinoma, Non-Small-Cell Lung / chemistry* Carcinoma, Non-Small-Cell Lung / pathology* Chimera Core Binding Factor Alpha 2 Subunit / analysis* Female Glutaredoxins / analysis* Humans Lung Neoplasms / chemistry* Lung Neoplasms / pathology* Male Middle Aged Neoplasm Recurrence, Local Neoplasm Staging Postoperative Period Predictive Value of Tests Prognosis Survival Analysis |
| IF | 1.914 |
| 引用数 | 0 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | CSII-CMV-MCS-IRES2-Bsd (RDB04385) |