論文 - 詳細
| RRC ID | 3571 |
|---|---|
| 著者 | Fujisawa K, Wrana JL, Culotti JG. |
| タイトル | The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans. |
| ジャーナル | Science |
| Abstract |
The SAX-3/roundabout (Robo) receptor has SLT-1/Slit-dependent and -independent functions in guiding cell and axon migrations. We identified enhancer of ventral-axon guidance defects of unc-40 mutants (EVA-1) as a Caenorhabditis elegans transmembrane receptor for SLT-1. EVA-1 has two predicted galactose-binding ectodomains, acts cell-autonomously for SLT-1/Slit-dependent axon migration functions of SAX-3/Robo, binds to SLT-1 and SAX-3, colocalizes with SAX-3 on cells, and provides cell specificity to the activation of SAX-3 signaling by SLT-1. Double mutants of eva-1 or slt-1 with sax-3 mutations suggest that SAX-3 can (when slt-1 or eva-1 function is reduced) inhibit a parallel-acting guidance mechanism, which involves UNC-40/deleted in colorectal cancer. |
| 巻・号 | 317(5846) |
| ページ | 1934-8 |
| 公開日 | 2007-9-28 |
| DOI | 10.1126/science.1144874 |
| PII | 317/5846/1934 |
| PMID | 17901337 |
| MeSH | Amino Acid Sequence Animals Animals, Genetically Modified Axons / physiology* Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / chemistry* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Carrier Proteins / chemistry Carrier Proteins / genetics Carrier Proteins / metabolism* Cell Line Cell Movement Cloning, Molecular Humans Molecular Sequence Data Mutation Nerve Tissue Proteins / metabolism* Nervous System / growth & development Nervous System / metabolism Neurons / physiology Protein Structure, Tertiary Receptors, Immunologic / metabolism* Recombinant Fusion Proteins / metabolism Signal Transduction |
| IF | 41.846 |
| 引用数 | 43 |
| WOS 分野 | CELL BIOLOGY |
| リソース情報 | |
| 線虫 | tm0974 |