Reference - Detail
|Author||Takahashi Y, Sawada G, Kurashige J, Uchi R, Matsumura T, Ueo H, Takano Y, Akiyoshi S, Eguchi H, Sudo T, Sugimachi K, Doki Y, Mori M, Mimori K.|
|Title||Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer.|
|Journal||Br J Cancer|
BACKGROUND:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated.
METHODS:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets.
RESULTS:PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC.
CONCLUSION:PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.
|MeSH||Carcinoma / diagnosis* Carcinoma / genetics Carcinoma / mortality Carcinoma / pathology* Cell Adhesion / genetics Cell Line, Tumor Cell Proliferation Colorectal Neoplasms / diagnosis* Colorectal Neoplasms / genetics Colorectal Neoplasms / mortality Colorectal Neoplasms / pathology* Epithelial-Mesenchymal Transition / genetics* Gene Expression Regulation, Neoplastic / physiology Homeodomain Proteins / genetics Homeodomain Proteins / physiology* Humans Meta-Analysis as Topic Neoplasm Metastasis Prognosis Survival Analysis Transfection Up-Regulation / genetics|
|DNA material||pCMV-VSV-G-RSV-Rev (RDB04393) pCAG-HIVgp (RDB04394) CSII-CMV-MCS (RDB04377).|