RRC ID 35722
Author Takahashi Y, Sawada G, Kurashige J, Uchi R, Matsumura T, Ueo H, Takano Y, Akiyoshi S, Eguchi H, Sudo T, Sugimachi K, Doki Y, Mori M, Mimori K.
Title Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer.
Journal Br J Cancer
Abstract BACKGROUND:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated.
METHODS:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets.
RESULTS:PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC.
CONCLUSION:PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.
Volume 109(2)
Pages 307-11
Published 2013-7-23
DOI 10.1038/bjc.2013.339
PII bjc2013339
PMID 23807160
PMC PMC3721401
MeSH Carcinoma / diagnosis* Carcinoma / genetics Carcinoma / mortality Carcinoma / pathology* Cell Adhesion / genetics Cell Line, Tumor Cell Proliferation Colorectal Neoplasms / diagnosis* Colorectal Neoplasms / genetics Colorectal Neoplasms / mortality Colorectal Neoplasms / pathology* Epithelial-Mesenchymal Transition / genetics* Gene Expression Regulation, Neoplastic / physiology Homeodomain Proteins / genetics Homeodomain Proteins / physiology* Humans Meta-Analysis as Topic Neoplasm Metastasis Prognosis Survival Analysis Transfection Up-Regulation / genetics
IF 5.791
Times Cited 46
DNA material pCMV-VSV-G-RSV-Rev (RDB04393) pCAG-HIVgp (RDB04394) CSII-CMV-MCS (RDB04377).