RRC ID 35924
Author Shao J, He Y, Li F, Zhang H, Chen A, Luo S, Gu JD.
Title Growth inhibition and possible mechanism of oleamide against the toxin-producing cyanobacterium Microcystis aeruginosa NIES-843.
Journal Ecotoxicology
Abstract Oleamide, a fatty acid derivative, shows inhibitory effect against the bloom-forming cyanobacterium Microcystis aeruginosa. The EC50 of oleamide on the growth of M. aeruginosa NIES-843 was 8.60 ± 1.20 mg/L. In order to elucidate the possible mechanism of toxicity of oleamide against M. aeruginosa, chlorophyll fluorescence transient, cellular ultrastructure, fatty acids composition and the transcription of the mcyB gene involved in microcystins synthesis were studied. The results of chlorophyll fluorescence transient showed that oleamide could destruct the electron accepting side of the photosystem II of M. aeruginosa NIES-843. Cellular ultrastructure examination indicated that the destruction of fatty acid constituents, the distortion of thylakoid membrane and the loss of integrity of cell membrane were associated with oleamide treatment and concentration. The damage of cellular membrane increased the release of microcystins from intact cells into the medium. Results presented in this study provide new information on the possible mechanisms involved and potential utilization of oleamide as an algicide in cyanobacterial bloom control.
Volume 25(1)
Pages 225-33
Published 2016-1-1
DOI 10.1007/s10646-015-1582-x
PII 10.1007/s10646-015-1582-x
PMID 26547872
MeSH Cell Membrane / drug effects Microcystins / metabolism* Microcystis / drug effects* Microcystis / genetics Microcystis / metabolism Microcystis / ultrastructure Oleic Acids / pharmacology* Pest Control Photosystem II Protein Complex / metabolism Thylakoids / drug effects
IF 2.535
Times Cited 5
Algae NIES-843