論文 - 詳細
| RRC ID | 35953 |
|---|---|
| 著者 | Zappia MP, Frolov MV. |
| タイトル | E2F function in muscle growth is necessary and sufficient for viability in Drosophila. |
| ジャーナル | Nat Commun |
| Abstract |
The E2F transcription factor is a key cell cycle regulator. However, the inactivation of the entire E2F family in Drosophila is permissive throughout most of animal development until pupation when lethality occurs. Here we show that E2F function in the adult skeletal muscle is essential for animal viability since providing E2F function in muscles rescues the lethality of the whole-body E2F-deficient animals. Muscle-specific loss of E2F results in a significant reduction in muscle mass and thinner myofibrils. We demonstrate that E2F is dispensable for proliferation of muscle progenitor cells, but is required during late myogenesis to directly control the expression of a set of muscle-specific genes. Interestingly, E2f1 provides a major contribution to the regulation of myogenic function, while E2f2 appears to be less important. These findings identify a key function of E2F in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells. |
| 巻・号 | 7 |
| ページ | 10509 |
| 公開日 | 2016-1-29 |
| DOI | 10.1038/ncomms10509 |
| PII | ncomms10509 |
| PMID | 26823289 |
| PMC | PMC4740182 |
| MeSH | Animals Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / metabolism* E2F1 Transcription Factor / genetics E2F1 Transcription Factor / metabolism* E2F2 Transcription Factor / genetics E2F2 Transcription Factor / metabolism* Female Gene Expression Regulation, Developmental / physiology Gene Knockdown Techniques Larva Male Muscle Development / genetics* Muscles / embryology* Pupa Trans-Activators / genetics Trans-Activators / metabolism* |
| IF | 12.121 |
| 引用数 | 16 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 4654R-2 |