論文 - 詳細
| RRC ID | 35977 |
|---|---|
| 著者 | Nozawa M, Fukuda N, Ikeo K, Gojobori T. |
| タイトル | Tissue- and stage-dependent dosage compensation on the neo-X chromosome in Drosophila pseudoobscura. |
| ジャーナル | Mol Biol Evol |
| Abstract |
Sex chromosome dosage compensation (DC) is widely accepted in various organisms. This concept is mostly supported by comparisons of gene expression between chromosomes and between sexes. However, genes on the X chromosome and autosomes are mostly not homologous, and the average gene expression level on these chromosomes may not be the same even under DC, which complicates comparisons between chromosomes. Many genes with sex-biased expression also make comparisons between sexes difficult. To overcome these issues, we investigated DC by comparing the expression of neo-X-linked genes in Drosophila pseudoobscura with those of their autosomal orthologs in other Drosophila species. The ratio of the former to the latter in males would be 1 under DC, whereas it becomes 0.5 without DC. We found that the ratio was ∼0.85 for adult whole bodies, indicating that the DC is incomplete on the neo-X chromosome in adults as a whole. The ratio (∼0.90) was also significantly less than 1 for adult bodies without gonads, whereas it was ∼1.0 for adult heads. These results indicate that DC varies among tissues. Our sliding-window analysis of the ratio also revealed that the upregulation of neo-X-linked genes in males occurred chromosome wide in all tissues analyzed, indicating global upregulation mechanisms. However, we found that gene functions also affected the levels of DC. Furthermore, most of the genes recently moved to the X were already under DC at the larval stage but not at the adult stage. These results suggest that DC in Drosophila species operates in a tissue/stage-dependent manner. |
| 巻・号 | 31(3) |
| ページ | 614-24 |
| 公開日 | 2014-3-1 |
| DOI | 10.1093/molbev/mst239 |
| PII | mst239 |
| PMID | 24307686 |
| MeSH | Animals Chromosomes, Insect / genetics* Dosage Compensation, Genetic* Drosophila / genetics* Drosophila / growth & development* Female Genes, Insect / genetics Larva / genetics Life Cycle Stages / genetics* Male Organ Specificity / genetics* X Chromosome / genetics* |
| IF | 11.062 |
| 引用数 | 14 |
| WOS 分野 | GENETICS & HEREDITY BIOCHEMISTRY & MOLECULAR BIOLOGY EVOLUTIONARY BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | D. pseudoobscura (K-s12) D. persimilis (K-s11) D. simulans (K-s05) and D. sechellia (K-s10) |