論文 - 詳細
| RRC ID | 35982 |
|---|---|
| 著者 | Seko D, Ogawa S, Li TS, Taimura A, Ono Y. |
| タイトル | μ-Crystallin controls muscle function through thyroid hormone action. |
| ジャーナル | FASEB J |
| Abstract |
μ-Crystallin (Crym), a thyroid hormone-binding protein, is abnormally up-regulated in the muscles of patients with facioscapulohumeral muscular dystrophy, a dominantly inherited progressive myopathy. However, the physiologic function of Crym in skeletal muscle remains to be elucidated. In this study, Crym was preferentially expressed in skeletal muscle throughout the body. Crym-knockout mice exhibited a significant hypertrophy of fast-twitch glycolytic type IIb fibers, causing an increase in grip strength and high intensity running ability in Crym-null mice. Genetic inactivation of Crym or blockade of Crym by siRNA-mediated knockdown up-regulated the gene expression of fast-glycolytic contractile fibers in satellite cell-derived myotubes in vitro These alterations in Crym-inactivated muscle were rescued by inhibition of thyroid hormone, even though Crym is a positive regulator of thyroid hormone action in nonmuscle cells. The results demonstrated that Crym is a crucial regulator of muscle plasticity, controlling metabolic and contractile properties of myofibers, and thus the selective inactivation of Crym may be a potential therapeutic target for muscle-wasting diseases, such as muscular dystrophies and age-related sarcopenia.-Seko, D., Ogawa, S., Li, T.-S., Taimura, A., Ono, Y. μ-Crystallin controls muscle function through thyroid hormone action. |
| 巻・号 | 30(5) |
| ページ | 1733-40 |
| 公開日 | 2016-5-1 |
| DOI | 10.1096/fj.15-280933 |
| PII | fj.15-280933 |
| PMID | 26718889 |
| MeSH | Animals Antithyroid Agents Crystallins / genetics Crystallins / metabolism* Mice Mice, Knockout Muscle, Skeletal / physiology* RNA Interference RNA, Small Interfering Satellite Cells, Skeletal Muscle / physiology* Thyroxine / genetics Thyroxine / metabolism* Triiodothyronine / genetics Triiodothyronine / metabolism* Up-Regulation mu-Crystallins |
| IF | 4.966 |
| 引用数 | 15 |
| WOS 分野 | BIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC04396 |