Reference - Detail
| RRC ID | 35986 |
|---|---|
| Author | Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK. |
| Title | Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis. |
| Journal | Science |
| Abstract |
Sepsis is a frequently fatal condition characterized by an uncontrolled and harmful host reaction to microbial infection. Despite the prevalence and severity of sepsis, we lack a fundamental grasp of its pathophysiology. Here we report that the cytokine interleukin-3 (IL-3) potentiates inflammation in sepsis. Using a mouse model of abdominal sepsis, we showed that innate response activator B cells produce IL-3, which induces myelopoiesis of Ly-6C(high) monocytes and neutrophils and fuels a cytokine storm. IL-3 deficiency protects mice against sepsis. In humans with sepsis, high plasma IL-3 levels are associated with high mortality even after adjusting for prognostic indicators. This study deepens our understanding of immune activation, identifies IL-3 as an orchestrator of emergency myelopoiesis, and reveals a new therapeutic target for treating sepsis. |
| Volume | 347(6227) |
| Pages | 1260-5 |
| Published | 2015-3-13 |
| DOI | 10.1126/science.aaa4268 |
| PII | 347/6227/1260 |
| PMID | 25766237 |
| PMC | PMC4376966 |
| MeSH | Animals B-Lymphocyte Subsets / immunology Cytokines / immunology Cytokines / metabolism Disease Models, Animal Humans Inflammation Interleukin-3 / blood Interleukin-3 / immunology* Interleukin-3 / metabolism Lipopolysaccharides / immunology Lymphoid Tissue / immunology Mice Mice, Inbred BALB C Monocytes / immunology Myelopoiesis Neutrophils / immunology Peritonitis / immunology Peritonitis / pathology Prognosis Sepsis / immunology* Sepsis / mortality Sepsis / pathology Sepsis / therapy |
| IF | 41.846 |
| Times Cited | 125 |
| WOS Category | IMMUNOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Google+ |
| Total number of mentions | 77 |
| Altmetric score changes over past 6months | 3.0 |
| Resource | |
| Mice | RBRC02298 |