論文 - 詳細
| RRC ID | 35993 |
|---|---|
| 著者 | Martinet V, Tonon S, Torres D, Azouz A, Nguyen M, Kohler A, Flamand V, Mao CA, Klein WH, Leo O, Goriely S. |
| タイトル | Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells. |
| ジャーナル | Nat Commun |
| Abstract |
CD8(+) T-cell memory phenotype and function are acquired after antigen-driven activation. Memory-like cells may also arise in absence of antigenic exposure in the thymus or in the periphery. Eomesodermin (Eomes) is a key transcription factor for the development of these unconventional memory cells. Herein, we show that type I interferon signalling in CD8(+) T cells directly activates Eomes gene expression. Consistent with this observation, the phenotype, function and age-dependent expansion of 'virtual memory' CD8(+) T cells are strongly affected in absence of type I interferon signalling. In addition, type I interferons induce a sustained expansion of 'virtual memory' CD8(+) T cells in an Eomes-dependent fashion. We further show that the development of 'innate thymic' CD8(+) T cells is dependent on the same pathway. In conclusion, we demonstrate that type I interferon signalling in CD8(+) T cells drives Eomes expression and thereby regulates the function and homeostasis of memory-like CD8(+) T cells. |
| 巻・号 | 6 |
| ページ | 7089 |
| 公開日 | 2015-5-8 |
| DOI | 10.1038/ncomms8089 |
| PII | ncomms8089 |
| PMID | 25953241 |
| PMC | PMC4432629 |
| MeSH | Animals Antigens / metabolism CD8-Positive T-Lymphocytes / drug effects CD8-Positive T-Lymphocytes / metabolism* Gene Expression Regulation / drug effects Homeostasis / drug effects Immunity, Innate / drug effects Immunologic Memory / drug effects Immunologic Memory / genetics* Interferon Type I / metabolism* Interferon-Stimulated Gene Factor 3, gamma Subunit / metabolism Interferon-gamma / biosynthesis Mice, Inbred BALB C Mice, Inbred C57BL Poly I-C / pharmacology Receptor, Interferon alpha-beta / deficiency Receptor, Interferon alpha-beta / metabolism Signal Transduction / drug effects T-Box Domain Proteins / genetics* T-Box Domain Proteins / metabolism Thymocytes / drug effects Thymocytes / metabolism |
| IF | 12.121 |
| 引用数 | 28 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC00915 |