Reference - Detail
| RRC ID | 36047 |
|---|---|
| Author | Tsuruyama T, Hiratsuka T, Aini W, Nakamura T. |
| Title | STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner. |
| Journal | J Cell Biochem |
| Abstract |
Signal transducer and activator of transcription 5A (STAT5A) contributes to B-cell responses to cytokines through suppressor of cytokine signaling (Socs) genes in innate immunity. However, its direct roles in B-cell responses to chemokines are poorly understood. In this study, we examined the role of STAT5A in the innate immune response. We found that STAT5A upregulated the transcription of C-C motif receptor 6 (Ccr6) to induce responses to its ligand, CCL20. STAT5A transcriptional activity proceeded through binding to the interferon-γ activation site (GAS) element in the CCR6 promoter in the genome of pre-B cells. High levels of STAT5A and CCR6 increased CCL20-dependent colony growth of pre-B cells. In human B-lymphoblastic lymphoma with inflammation, STAT5A phosphorylation was correlated with CCR6 expression (P > 0.05 compared with that in cases without inflammation). In conclusion, our data supported our hypothesis that STAT5A enhanced the response of pre-B cells to CCL20 to promote their growth. J. Cell. Biochem. 117: 2630-2642, 2016. © 2016 Wiley Periodicals, Inc. |
| Volume | 117(11) |
| Pages | 2630-42 |
| Published | 2016-11-1 |
| DOI | 10.1002/jcb.25558 |
| PMID | 27018255 |
| MeSH | Animals Apoptosis Blotting, Western Cell Proliferation Cells, Cultured Chemokine CCL20 / genetics Chemokine CCL20 / metabolism* Cytokines / genetics Cytokines / metabolism Humans Immunoenzyme Techniques Inflammation / genetics Inflammation / metabolism Inflammation / pathology* Lymphoma, B-Cell / genetics Lymphoma, B-Cell / metabolism Lymphoma, B-Cell / pathology* Mice Phosphorylation Precursor Cells, B-Lymphoid / cytology* Precursor Cells, B-Lymphoid / metabolism RNA, Messenger / genetics Real-Time Polymerase Chain Reaction Receptors, CCR6 / genetics Receptors, CCR6 / metabolism* Reverse Transcriptase Polymerase Chain Reaction STAT5 Transcription Factor / genetics STAT5 Transcription Factor / metabolism* Signal Transduction |
| IF | 4.237 |
| Times Cited | 7 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Mice | RBRC00222 |