Reference - Detail
| RRC ID | 3607 |
|---|---|
| Author | Mukhopadhyay S, Lu Y, Qin H, Lanjuin A, Shaham S, Sengupta P. |
| Title | Distinct IFT mechanisms contribute to the generation of ciliary structural diversity in C. elegans. |
| Journal | EMBO J |
| Abstract |
Individual cell types can elaborate morphologically diverse cilia. Cilia are assembled via intraflagellar transport (IFT) of ciliary precursors; however, the mechanisms that generate ciliary diversity are unknown. Here, we examine IFT in the structurally distinct cilia of the ASH/ASI and the AWB chemosensory neurons in Caenorhabditis elegans, enabling us to compare IFT in specific cilia types. We show that unlike in the ASH/ASI cilia, the OSM-3 kinesin moves independently of the kinesin-II motor in the AWB cilia. Although OSM-3 is essential to extend the distal segments of the ASH/ASI cilia, it is not required to build the AWB distal segments. Mutations in the fkh-2 forkhead domain gene result in AWB-specific defects in ciliary morphology, and FKH-2 regulates kinesin-II subunit gene expression specifically in AWB. Our results suggest that cell-specific regulation of IFT contributes to the generation of ciliary diversity, and provide insights into the networks coupling the acquisition of ciliary specializations with other aspects of cell fate. |
| Volume | 26(12) |
| Pages | 2966-80 |
| Published | 2007-6-20 |
| DOI | 10.1038/sj.emboj.7601717 |
| PII | 7601717 |
| PMID | 17510633 |
| PMC | PMC1894762 |
| MeSH | Animals Animals, Genetically Modified Biological Transport Caenorhabditis elegans / cytology* Caenorhabditis elegans Proteins / physiology Cilia / ultrastructure* Kinesins / physiology Microscopy, Electron Mutation Olfactory Receptor Neurons / ultrastructure |
| IF | 9.889 |
| Times Cited | 65 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | F1000Research |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm324 |