Reference - Detail
| RRC ID | 3609 |
|---|---|
| Author | Nakao F, Hudson ML, Suzuki M, Peckler Z, Kurokawa R, Liu Z, Gengyo-Ando K, Nukazuka A, Fujii T, Suto F, Shibata Y, Shioi G, Fujisawa H, Mitani S, Chisholm AD, Takagi S. |
| Title | The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis. |
| Journal | Genetics |
| Abstract |
Semaphorins are extracellular proteins that regulate axon guidance and morphogenesis by interacting with a variety of cell surface receptors. Most semaphorins interact with plexin-containing receptor complexes, although some interact with non-plexin receptors. Class 2 semaphorins are secreted molecules that control axon guidance and epidermal morphogenesis in Drosophila and Caenorhabditis elegans. We show that the C. elegans class 2 semaphorin MAB-20 binds the plexin PLX-2. plx-2 mutations enhance the phenotypes of hypomorphic mab-20 alleles but not those of mab-20 null alleles, indicating that plx-2 and mab-20 act in a common pathway. Both mab-20 and plx-2 mutations affect epidermal morphogenesis during embryonic and in postembryonic development. In both contexts, plx-2 null mutant phenotypes are much less severe than mab-20 null phenotypes, indicating that PLX-2 is not essential for MAB-20 signaling. Mutations in the ephrin efn-4 do not synergize with mab-20, indicating that EFN-4 may act in MAB-20 signaling. EFN-4 and PLX-2 are coexpressed in the late embryonic epidermis where they play redundant roles in MAB-20-dependent cell sorting. |
| Volume | 176(3) |
| Pages | 1591-607 |
| Published | 2007-7-1 |
| DOI | 10.1534/genetics.106.067116 |
| PII | genetics.106.067116 |
| PMID | 17507686 |
| PMC | PMC1931547 |
| MeSH | Animals Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / metabolism* Caenorhabditis elegans Proteins / physiology Cell Adhesion Molecules / physiology* Ephrin-A4 / physiology* Membrane Proteins / metabolism* Morphogenesis* Nerve Tissue Proteins / metabolism* Nerve Tissue Proteins / physiology* Semaphorins / metabolism* Signal Transduction |
| IF | 4.015 |
| Times Cited | 20 |
| WOS Category | GENETICS & HEREDITY |
| Altmetric score |
オルトメトリクス指標項目
|
| Total number of mentions | 0 |
| Resource | |
| C.elegans | tm729 |