論文 - 詳細
| RRC ID | 36125 |
|---|---|
| 著者 | Enriquez J, Venkatasubramanian L, Baek M, Peterson M, Aghayeva U, Mann RS. |
| タイトル | Specification of individual adult motor neuron morphologies by combinatorial transcription factor codes. |
| ジャーナル | Neuron |
| Abstract |
How the highly stereotyped morphologies of individual neurons are genetically specified is not well understood. We identify six transcription factors (TFs) expressed in a combinatorial manner in seven post-mitotic adult leg motor neurons (MNs) that are derived from a single neuroblast in Drosophila. Unlike TFs expressed in mitotically active neuroblasts, these TFs do not regulate each other's expression. Removing the activity of a single TF resulted in specific morphological defects, including muscle targeting and dendritic arborization, and in a highly specific walking defect in adult flies. In contrast, when the expression of multiple TFs was modified, nearly complete transformations in MN morphologies were generated. These results show that the morphological characteristics of a single neuron are dictated by a combinatorial code of morphology TFs (mTFs). mTFs function at a previously unidentified regulatory tier downstream of factors acting in the NB but independently of factors that act in terminally differentiated neurons. |
| 巻・号 | 86(4) |
| ページ | 955-970 |
| 公開日 | 2015-5-20 |
| DOI | 10.1016/j.neuron.2015.04.011 |
| PII | S0896-6273(15)00340-2 |
| PMID | 25959734 |
| PMC | PMC4441546 |
| MeSH | Animals Cell Differentiation / genetics Cell Differentiation / physiology Cell Lineage Dendrites / metabolism Dendrites / pathology* Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster Gene Expression Regulation, Developmental / physiology* Homeodomain Proteins / genetics Homeodomain Proteins / metabolism* Motor Neurons / cytology Motor Neurons / metabolism* Transcription Factors / metabolism* |
| IF | 14.415 |
| 引用数 | 33 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | UAS-toy (Kyoto stock center) |