RRC ID 36238
Author Takahashi KH.
Title Novel genetic capacitors and potentiators for the natural genetic variation of sensory bristles and their trait specificity in Drosophila melanogaster.
Journal Mol. Ecol.
Abstract Cryptic genetic variation (CGV) is defined as the genetic variation that has little effect on phenotypic variation under a normal condition, but contributes to heritable variation under environmental or genetic perturbations. Genetic buffering systems that suppress the expression of CGV and store it in a population are called genetic capacitors, and the opposite systems are called genetic potentiators. One of the best-known candidates for a genetic capacitor and potentiator is the molecular chaperone protein, HSP90, and one of its characteristics is that it affects the genetic variation in various morphological traits. However, it remains unclear whether the wide-ranging effects of HSP90 on a broad range of traits are a general feature of genetic capacitors and potentiators. In the current study, I searched for novel genetic capacitors and potentiators for quantitative bristle traits of Drosophila melanogaster and then investigated the trait specificity of their genetic buffering effect. Three bristle traits of D. melanogaster were used as the target traits, and the genomic regions with genetic buffering effects were screened using the 61 genomic deficiencies examined previously for genetic buffering effects in wing shape. As a result, four and six deficiencies with significant effects on increasing and decreasing the broad-sense heritability of the bristle traits were identified, respectively. Of the 18 deficiencies with significant effects detected in the current study and/or by the previous study, 14 showed trait-specific effects, and four affected the genetic buffering of both bristle traits and wing shape. This suggests that most genetic capacitors and potentiators exert trait-specific effects, but that general capacitors and potentiators with effects on multiple traits also exist.
Volume 24(22)
Pages 5561-72
Published 2015-11
DOI 10.1111/mec.13407
PMID 26441383
MeSH Animals Drosophila melanogaster / anatomy & histology Drosophila melanogaster / genetics* Female Genetic Variation* Genotype Male Phenotype Quantitative Trait Loci Quantitative Trait, Heritable* Sensilla / anatomy & histology* Wings, Animal / anatomy & histology
IF 6.131
Times Cited 2
WOS Category ECOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY EVOLUTIONARY BIOLOGY
Resource
Drosophila Ehime-Fly (E-10020 ISGC8 Okinawa 2002 E-10010 MYH99-2 Okinawa 1999 E-10110 IHYS3 Okinawa 2004 E-10004 OZ89-1 Ehime 1989 E-10060 OKY1 Okayama 2004 E-10001 Hikone-R Shiga 1952 E-10166 OGSC11 Tokyo 2003 E-10017 FKC4 Fukui 2002 E-10126 YSG31 Yamagata 2006 E-10013 SPP9 Hokkaido 2002) 61 DrosDel isogenic deficiency strains: Df(2L)ED1164 (DGRC#150313) Df(2L)ED1183 (DGRC#150314) Df(2L)ED1186 (DGRC#150109) Df(2L)ED1196 (DGRC#150111) Df(2L)ED1317 (DGRC#150409) Df(2L)ED13216 (DGRC#150058) Df(2L)ED1454 (DGRC#150021) Df(2L)ED2809 (DGRC#150415) Df(2L)ED3 (DGRC#130378 or DGRC#150222) Df(2L)ED373 (DGRC#150287) Df(2L)ED463 (DGRC#150079) Df(2L)ED4651 (DGRC#150040) Df(2L)ED692 (DGRC#150393) Df(2L)ED776 (DGRC#150301) Df(2L)ED778 (DGRC#150398) Df(2R)ED1552 (DGRC#150410) Df(2R)ED1735 (DGRC#150027) Df(2R)ED1742 (DGRC#150028) Df(2R)ED1770 (DGRC#150510) Df(2R)ED1791 (DGRC#150124) Df(2R)ED2219 (DGRC#150031) Df(2R)ED2436 (DGRC#150035) Df(2R)ED3610 (DGRC#150126) Df(2R)ED3683 (DGRC#150039) Df(2R)ED3952 (DGRC#150130) Df(2R)ED9045 (DGRC#150263) Df(3L)ED207 (DGRC#150275) Df(3L)ED223 (DGRC#150280) Df(3L)ED225 (DGRC#150282) Df(3L)ED228 (DGRC#150283) Df(3L)ED230 (DGRC#150073) Df(3L)ED4341 (DGRC#150321 or DGRC#150425) Df(3L)ED4421 (DGRC#150230) Df(3L)ED4543 (DGRC#150434) Df(3L)ED4606 (DGRC#150324) Df(3L)ED4685 (DGRC#150436) Df(3L)ED4858 (DGRC#150232 or DGRC#150233) Df(3L)ED4978 (DGRC#150442) Df(3L)ED5013 (DGRC#150235) Df(3R)ED10556 (DGRC#150357) Df(3R)ED10564 (DGRC#150360) Df(3R)ED10566 (DGRC#150361) Df(3R)ED10811 (DGRC#150267) Df(3R)ED10893 (DGRC#150362) Df(3R)ED13102 (DGRC#150484) Df(3R)ED5046 (DGRC#150446) Df(3R)ED5100 (DGRC#150237) Df(3R)ED5511 (DGRC#150487) Df(3R)ED5514 (DGRC#150152) Df(3R)ED5518 (DGRC#150153) Df(3R)ED5657 (DGRC#150330) Df(3R)ED5660 (DGRC#150331) Df(3R)ED5662 (DGRC#150332) Df(3R)ED5664 (DGRC#150333) Df(3R)ED5688 (DGRC#150334) Df(3R)ED5807 (DGRC#150246) Df(3R)ED5911 (DGRC#150047) Df(3R)ED6058 (DGRC#150251) Df(3R)ED6103 (DGRC#150050) Df(3R)ED6119 (DGRC#150338) Df(3R)ED6316 (DGRC#150475)