論文 - 詳細
| RRC ID | 36255 |
|---|---|
| 著者 | Cetera M, Ramirez-San Juan GR, Oakes PW, Lewellyn L, Fairchild MJ, Tanentzapf G, Gardel ML, Horne-Badovinac S. |
| タイトル | Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation. |
| ジャーナル | Nat Commun |
| Abstract |
Tissues use numerous mechanisms to change shape during development. The Drosophila egg chamber is an organ-like structure that elongates to form an elliptical egg. During elongation the follicular epithelial cells undergo a collective migration that causes the egg chamber to rotate within its surrounding basement membrane. Rotation coincides with the formation of a 'molecular corset', in which actin bundles in the epithelium and fibrils in the basement membrane are all aligned perpendicular to the elongation axis. Here we show that rotation plays a critical role in building the actin-based component of the corset. Rotation begins shortly after egg chamber formation and requires lamellipodial protrusions at each follicle cell's leading edge. During early stages, rotation is necessary for tissue-level actin bundle alignment, but it becomes dispensable after the basement membrane is polarized. This work highlights how collective cell migration can be used to build a polarized tissue organization for organ morphogenesis. |
| 巻・号 | 5 |
| ページ | 5511 |
| 公開日 | 2014-11-21 |
| DOI | 10.1038/ncomms6511 |
| PII | ncomms6511 |
| PMID | 25413675 |
| PMC | PMC4241503 |
| MeSH | Actins Animals Cadherins / genetics Carrier Proteins / genetics Cell Movement Cell Polarity Contractile Proteins / metabolism* Drosophila Proteins / genetics Drosophila melanogaster / embryology* Eye Proteins / genetics Homeodomain Proteins / genetics Microfilament Proteins / genetics Morphogenesis Oogenesis / genetics* Ovum / growth & development* Pseudopodia / metabolism* RNA Interference RNA, Small Interfering Transcription Factors / genetics |
| IF | 12.121 |
| 引用数 | 92 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#104055 |