| RRC ID |
36288
|
| Author |
Lin AC, Bygrave AM, de Calignon A, Lee T, Miesenböck G.
|
| Title |
Sparse, decorrelated odor coding in the mushroom body enhances learned odor discrimination.
|
| Journal |
Nat Neurosci
|
| Abstract |
Sparse coding may be a general strategy of neural systems for augmenting memory capacity. In Drosophila melanogaster, sparse odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of precisely addressable locations for the storage of odor-specific memories. However, it remains untested how sparse coding relates to behavioral performance. Here we demonstrate that sparseness is controlled by a negative feedback circuit between Kenyon cells and the GABAergic anterior paired lateral (APL) neuron. Systematic activation and blockade of each leg of this feedback circuit showed that Kenyon cells activated APL and APL inhibited Kenyon cells. Disrupting the Kenyon cell-APL feedback loop decreased the sparseness of Kenyon cell odor responses, increased inter-odor correlations and prevented flies from learning to discriminate similar, but not dissimilar, odors. These results suggest that feedback inhibition suppresses Kenyon cell activity to maintain sparse, decorrelated odor coding and thus the odor specificity of memories.
|
| Volume |
17(4)
|
| Pages |
559-68
|
| Published |
2014-4-1
|
| DOI |
10.1038/nn.3660
|
| PII |
nn.3660
|
| PMID |
24561998
|
| PMC |
PMC4000970
|
| MeSH |
Animals
Animals, Genetically Modified
Behavior, Animal / physiology
Discrimination, Psychological / physiology
Drosophila Proteins / genetics
Drosophila melanogaster / physiology
Feedback, Physiological / physiology
GABAergic Neurons / cytology
GABAergic Neurons / metabolism
GABAergic Neurons / physiology
Learning / physiology*
Mushroom Bodies / cytology
Mushroom Bodies / physiology*
Neural Inhibition / physiology
Odorants
Olfactory Perception / physiology*
Up-Regulation / physiology*
|
| IF |
20.071
|
| Times Cited |
101
|
|
WOS Category
|
NEUROSCIENCES
|
| Resource |
| Drosophila |
DGRC#104266 |
