RRC ID 36309
Author Tastekin I, Riedl J, Schilling-Kurz V, Gomez-Marin A, Truman JW, Louis M.
Title Role of the subesophageal zone in sensorimotor control of orientation in Drosophila larva.
Journal Curr Biol
Abstract Chemotaxis is a powerful paradigm to investigate how nervous systems represent and integrate changes in sensory signals to direct navigational decisions. In the Drosophila melanogaster larva, chemotaxis mainly consists of an alternation of distinct behavioral modes: runs and directed turns. During locomotion, turns are triggered by the integration of temporal changes in the intensity of the stimulus. Upon completion of a turning maneuver, the direction of motion is typically realigned toward the odor gradient. While the anatomy of the peripheral olfactory circuits and the locomotor system of the larva are reasonably well documented, the neural circuits connecting the sensory neurons to the motor neurons remain unknown. We combined a loss-of-function behavioral screen with optogenetics-based clonal gain-of-function manipulations to identify neurons that are necessary and sufficient for the initiation of reorientation maneuvers in odor gradients. Our results indicate that a small subset of neurons residing in the subesophageal zone controls the rate of transition from runs to turns-a premotor function compatible with previous observations made in other invertebrates. After having shown that this function pertains to the processing of inputs from different sensory modalities (olfaction, vision, thermosensation), we conclude that the subesophageal zone operates as a general premotor center that regulates the selection of different behavioral programs based on the integration of sensory stimuli. The present analysis paves the way for a systematic investigation of the neural computations underlying action selection in a miniature brain amenable to genetic manipulations.
Volume 25(11)
Pages 1448-60
Published 2015-6-1
DOI 10.1016/j.cub.2015.04.016
PII S0960-9822(15)00429-7
PMID 25959970
MeSH Animals Drosophila / physiology* Feedback, Sensory* Female Larva / physiology Male Neurons / physiology* Orientation / physiology* Phenotype
IF 9.193
Times Cited 26
WOS Category BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
Resource
Drosophila DGRC#103747 DGRC#103786 DGRC#103813 DGRC#103963 DGRC#104060 DGRC#104104 DGRC#104237 DGRC#104511 DGRC#104553 DGRC#104798 DGRC#104870 DGRC#104941 DGRC#105201 DGRC#112697 DGRC#112896 DGRC#112972 DGRC#113094 DGRC#113495 DGRC#113606 DGRC#113885 DGRC#113938 DGRC#114247 DGRC#114253 DGRC#114255 over 1 100 P[GAL4] enhancer trap lines (NP-GAL4)