Reference - Detail
| RRC ID | 36354 |
|---|---|
| Author | Hamamoto H, Sekimizu K. |
| Title | Identification of lysocin E using a silkworm model of bacterial infection. |
| Journal | Drug Discov Ther |
| Abstract |
New antimicrobials with novel mechanisms need to be developed to combat antimicrobial-resistant pathogenic bacteria. The current authors recently reported discovery of a new antibiotic named "Lysocin E". Lysocin E was identified using a silkworm model of bacterial infection. The current review discusses the advantages of using a silkworm model of bacterial infection to identify and develop therapeutically efficacious antimicrobials. This review also discusses the discovery of lysocin E and its novel mechanism of action. |
| Volume | 10(1) |
| Pages | 24-9 |
| Published | 2016-2-1 |
| DOI | 10.5582/ddt.2016.01012 |
| PMID | 26911796 |
| MeSH | Animals Anti-Bacterial Agents / pharmacology* Bacterial Infections / drug therapy* Bacterial Infections / microbiology Bombyx / drug effects* Bombyx / embryology Bombyx / microbiology Disease Models, Animal Drug Discovery / methods* Drug Resistance, Multiple, Bacterial Humans Larva / drug effects Larva / microbiology Molecular Structure Peptides, Cyclic / pharmacology* Species Specificity |
| Times Cited | 1 |
| Resource | |
| Silkworms | |