論文 - 詳細
| RRC ID | 3641 |
|---|---|
| 著者 | Von Stetina SE, Fox RM, Watkins KL, Starich TA, Shaw JE, Miller DM 3rd. |
| タイトル | UNC-4 represses CEH-12/HB9 to specify synaptic inputs to VA motor neurons in C. elegans. |
| ジャーナル | Genes Dev |
| Abstract |
In Caenorhabditis elegans, VA and VB motor neurons arise as lineal sisters but synapse with different interneurons to regulate locomotion. VA-specific inputs are defined by the UNC-4 homeoprotein and its transcriptional corepressor, UNC-37/Groucho, which function in the VAs to block the creation of chemical synapses and gap junctions with interneurons normally reserved for VBs. To reveal downstream genes that control this choice, we have employed a cell-specific microarray strategy that has now identified unc-4-regulated transcripts. One of these genes, ceh-12, a member of the HB9 family of homeoproteins, is normally restricted to VBs. We show that expression of CEH-12/HB9 in VA motor neurons in unc-4 mutants imposes VB-type inputs. Thus, this work reveals a developmental switch in which motor neuron input is defined by differential expression of transcription factors that select alternative presynaptic partners. The conservation of UNC-4, HB9, and Groucho expression in the vertebrate motor circuit argues that similar mechanisms may regulate synaptic specificity in the spinal cord. |
| 巻・号 | 21(3) |
| ページ | 332-46 |
| 公開日 | 2007-2-1 |
| DOI | 10.1101/gad.1502107 |
| PII | 21/3/332 |
| PMID | 17289921 |
| PMC | PMC1785118 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Caenorhabditis elegans Proteins / physiology Gap Junctions Gene Expression Regulation Homeodomain Proteins / genetics Homeodomain Proteins / physiology* Models, Biological Motor Neurons / physiology* Movement / physiology Nuclear Proteins / genetics Nuclear Proteins / physiology* Synaptic Transmission* / genetics Transcription Factors / metabolism* Transcription Factors / physiology |
| IF | 9.527 |
| 引用数 | 36 |
| WOS 分野 | GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1619 |