論文 - 詳細
| RRC ID | 36445 |
|---|---|
| 著者 | McCairn KW, Nagai Y, Hori Y, Ninomiya T, Kikuchi E, Lee JY, Suhara T, Iriki A, Minamimoto T, Takada M, Isoda M, Matsumoto M. |
| タイトル | A Primary Role for Nucleus Accumbens and Related Limbic Network in Vocal Tics. |
| ジャーナル | Neuron |
| Abstract |
Inappropriate vocal expressions, e.g., vocal tics in Tourette syndrome, severely impact quality of life. Neural mechanisms underlying vocal tics remain unexplored because no established animal model representing the condition exists. We report that unilateral disinhibition of the nucleus accumbens (NAc) generates vocal tics in monkeys. Whole-brain PET imaging identified prominent, bilateral limbic cortico-subcortical activation. Local field potentials (LFPs) developed abnormal spikes in the NAc and the anterior cingulate cortex (ACC). Vocalization could occur without obvious LFP spikes, however, when phase-phase coupling of alpha oscillations were accentuated between the NAc, ACC, and the primary motor cortex. These findings contrasted with myoclonic motor tics induced by disinhibition of the dorsolateral putamen, where PET activity was confined to the ipsilateral sensorimotor system and LFP spikes always preceded motor tics. We propose that vocal tics emerge as a consequence of dysrhythmic alpha coupling between critical nodes in the limbic and motor networks. VIDEO ABSTRACT. |
| 巻・号 | 89(2) |
| ページ | 300-7 |
| 公開日 | 2016-1-20 |
| DOI | 10.1016/j.neuron.2015.12.025 |
| PII | S0896-6273(15)01127-7 |
| PMID | 26796690 |
| MeSH | Action Potentials / physiology* Animals Limbic System / physiology* Macaca mulatta Male Nerve Net / physiology* Nucleus Accumbens / physiology* Tics / physiopathology* Vocalization, Animal / physiology* |
| IF | 14.415 |
| 引用数 | 31 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 24 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ニホンザル | |