Reference - Detail
| RRC ID | 36657 |
|---|---|
| Author | Ota M, Serada S, Naka T, Mori Y. |
| Title | MHC class I molecules are incorporated into human herpesvirus-6 viral particles and released into the extracellular environment. |
| Journal | Microbiol Immunol |
| Abstract |
Human herpesvirus-6 (HHV-6), which belongs to the betaherpesvirus subfamily, mainly replicates in T lymphocytes. Here, we show that MHC class I molecules are incorporated into HHV-6 viral particles and released into the extracellular environment. In addition, HHV-6A/B-infected T cells showed reduced surface and intracellular expression of MHC class I molecules. The cellular machinery responsible for molecular transport appears to be modified upon HHV-6 infection, causing MHC class I molecules to be transported to virion assembly sites. |
| Volume | 58(2) |
| Pages | 119-25 |
| Published | 2014-2-1 |
| DOI | 10.1111/1348-0421.12121 |
| PMID | 24330265 |
| MeSH | Cell Line Down-Regulation Exosomes / metabolism Extracellular Space / metabolism Herpesvirus 6, Human / immunology Herpesvirus 6, Human / physiology* Histocompatibility Antigens Class I / metabolism* Humans Models, Biological Protein Transport Subcellular Fractions / metabolism Virion* / immunology |
| IF | 1.566 |
| Times Cited | 17 |
| WOS Category | IMMUNOLOGY MICROBIOLOGY |
| Resource | |
| Cord blood stem cells for research | 研究用ヒト臍帯血幹細胞 |