RRC ID 36670
Author Jasirwan C, Tang H, Kawabata A, Mori Y.
Title The human herpesvirus 6 U21-U24 gene cluster is dispensable for virus growth.
Journal Microbiol. Immunol.
Abstract Human herpesvirus 6 (HHV-6) is a T-lymphotrophic virus belongs to the genus Roseolovirus within the beta herpesvirus subfamily. The U20-U24 gene cluster is unique to Roseoloviruses; however, both their function and whether they are essential for virus growth is unknown. Recently, bacterial artificial chromosome (BAC) techniques have been used to investigate HHV-6A. This study describes generation of a virus genome lacking U21-U24 (HHV-6ABACΔU21-24) and shows that infectious virus particles can be reconstituted from this BAC DNA. Our data indicate that the HHV-6 U21-U24 gene cluster is dispensable for virus propagation.
Volume 59(1)
Pages 48-53
Published 2015-1
DOI 10.1111/1348-0421.12208
PMID 25346365
MeSH Chromosomes, Artificial, Bacterial Gene Deletion Genes, Viral* Herpesvirus 6, Human / genetics Herpesvirus 6, Human / growth & development Herpesvirus 6, Human / physiology* Multigene Family* Reverse Genetics Viral Proteins / genetics Viral Proteins / metabolism* Virion / physiology Virus Replication*
IF 1.335
Times Cited 0
WOS Category IMMUNOLOGY MICROBIOLOGY
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