RRC ID 36677
Author Mahmoud NF, Jasirwan C, Kanemoto S, Wakata A, Wang B, Hata Y, Nagamata S, Kawabata A, Tang H, Mori Y.
Title Cytoplasmic tail domain of glycoprotein B is essential for HHV-6 infection.
Journal Virology
Abstract Human herpesvirus 6 (HHV-6) glycoprotein B (gB) is an abundantly expressed viral glycoprotein required for viral entry and cell fusion, and is highly conserved among herpesviruses. The present study examined the function of HHV-6 gB cytoplasmic tail domain (CTD). A gB CTD deletion mutant was constructed which, in contrast to its revertant, could not be reconstituted. Moreover, deletion of gB cytoplasmic tail impaired the intracellular transport of gB protein to the trans-Golgi network (TGN). Taken together, these results suggest that gB CTD is critical for HHV-6 propagation and important for intracellular transportation.
Volume 490
Pages 1-5
Published 2016-3-1
DOI 10.1016/j.virol.2015.12.018
PII S0042-6822(15)00539-5
PMID 26802210
MeSH Herpesvirus 6, Human / chemistry Herpesvirus 6, Human / genetics Herpesvirus 6, Human / growth & development Herpesvirus 6, Human / metabolism* Humans Protein Structure, Tertiary Roseolovirus Infections / virology* Viral Envelope Proteins / chemistry* Viral Envelope Proteins / genetics Viral Envelope Proteins / metabolism* trans-Golgi Network / virology
IF 2.819
Times Cited 3
Cord blood stem cells for research 研究用ヒト臍帯血幹細胞