| RRC ID |
36677
|
| Author |
Mahmoud NF, Jasirwan C, Kanemoto S, Wakata A, Wang B, Hata Y, Nagamata S, Kawabata A, Tang H, Mori Y.
|
| Title |
Cytoplasmic tail domain of glycoprotein B is essential for HHV-6 infection.
|
| Journal |
Virology
|
| Abstract |
Human herpesvirus 6 (HHV-6) glycoprotein B (gB) is an abundantly expressed viral glycoprotein required for viral entry and cell fusion, and is highly conserved among herpesviruses. The present study examined the function of HHV-6 gB cytoplasmic tail domain (CTD). A gB CTD deletion mutant was constructed which, in contrast to its revertant, could not be reconstituted. Moreover, deletion of gB cytoplasmic tail impaired the intracellular transport of gB protein to the trans-Golgi network (TGN). Taken together, these results suggest that gB CTD is critical for HHV-6 propagation and important for intracellular transportation.
|
| Volume |
490
|
| Pages |
1-5
|
| Published |
2016-3-1
|
| DOI |
10.1016/j.virol.2015.12.018
|
| PII |
S0042-6822(15)00539-5
|
| PMID |
26802210
|
| MeSH |
Herpesvirus 6, Human / chemistry
Herpesvirus 6, Human / genetics
Herpesvirus 6, Human / growth & development
Herpesvirus 6, Human / metabolism*
Humans
Protein Structure, Tertiary
Roseolovirus Infections / virology*
Viral Envelope Proteins / chemistry*
Viral Envelope Proteins / genetics
Viral Envelope Proteins / metabolism*
trans-Golgi Network / virology
|
| IF |
2.819
|
| Times Cited |
3
|
|
WOS Category
|
VIROLOGY
|
| Resource |
| Cord blood stem cells for research |
研究用ヒト臍帯血幹細胞 |
