RRC ID 36677
著者 Mahmoud NF, Jasirwan C, Kanemoto S, Wakata A, Wang B, Hata Y, Nagamata S, Kawabata A, Tang H, Mori Y.
タイトル Cytoplasmic tail domain of glycoprotein B is essential for HHV-6 infection.
ジャーナル Virology
Abstract Human herpesvirus 6 (HHV-6) glycoprotein B (gB) is an abundantly expressed viral glycoprotein required for viral entry and cell fusion, and is highly conserved among herpesviruses. The present study examined the function of HHV-6 gB cytoplasmic tail domain (CTD). A gB CTD deletion mutant was constructed which, in contrast to its revertant, could not be reconstituted. Moreover, deletion of gB cytoplasmic tail impaired the intracellular transport of gB protein to the trans-Golgi network (TGN). Taken together, these results suggest that gB CTD is critical for HHV-6 propagation and important for intracellular transportation.
巻・号 490
ページ 1-5
公開日 2016-3-1
DOI 10.1016/j.virol.2015.12.018
PII S0042-6822(15)00539-5
PMID 26802210
MeSH Herpesvirus 6, Human / chemistry Herpesvirus 6, Human / genetics Herpesvirus 6, Human / growth & development Herpesvirus 6, Human / metabolism* Humans Protein Structure, Tertiary Roseolovirus Infections / virology* Viral Envelope Proteins / chemistry* Viral Envelope Proteins / genetics Viral Envelope Proteins / metabolism* trans-Golgi Network / virology
IF 2.819
引用数 3
WOS 分野 VIROLOGY
リソース情報
研究用ヒト臍帯血幹細胞 研究用ヒト臍帯血幹細胞