| RRC ID |
36736
|
| Author |
Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko K, Munakata H, Endo Y, Fujita T, Sugamura K.
|
| Title |
Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
We molecularly cloned a cDNA coding for a novel phosphotyrosine molecule with a 70 kDa molecular mass, named STAM (signal transducing adaptor molecule), which is tyrosine-phosphorylated rapidly after stimulation with various cytokines such as IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF. STAM contains an SH3 (Src-homology 3) domain and the ITAM (immunoreceptor tyrosine-based activation motif), suggesting that STAM acts as an adaptor molecule involved in signal transducing pathways from the cytokine receptors.
|
| Volume |
225(3)
|
| Pages |
1035-9
|
| Published |
1996-8-23
|
| DOI |
10.1006/bbrc.1996.1290
|
| PII |
S0006-291X(96)91290-5
|
| PMID |
8780729
|
| MeSH |
Adaptor Proteins, Signal Transducing*
Amino Acid Sequence
Animals
Cell Line
Chromosome Mapping
Cloning, Molecular
Cytokines / pharmacology
DNA, Complementary / genetics
Endosomal Sorting Complexes Required for Transport
Humans
Mice
Molecular Sequence Data
Molecular Weight
Phosphoproteins / chemistry
Phosphoproteins / genetics*
Phosphoproteins / metabolism
Phosphorylation
Proteins / chemistry
Proteins / genetics*
Proteins / metabolism
Receptors, Cytokine / metabolism
Sequence Homology, Amino Acid
Signal Transduction*
Tyrosine / metabolism
src Homology Domains
|
| IF |
2.985
|
| Times Cited |
66
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| DNA material |
pBluescript-STAM-1 (RDB01792) |
