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  • Search Condition : Filter (MeSH = src Homology Domains)
Species Resource Title
Drosophila 11098R-3 , DGRC#110692 p24-Tango1 interactions ensure ER-Golgi interface stability and efficient transport.
Human and Animal Cells DT40(RCB1464) , Syk^(-) DT40(RCB1470) Targeting lipid-protein interaction to treat Syk-mediated acute myeloid leukemia.
Human and Animal Cells MDCK(RCB0995) Real-time visualization of PH domain-dependent translocation of phospholipase C-delta1 in renal epithelial cells (MDCK): response to hypo-osmotic stress.
Human and Animal Cells DT40(RCB1464) , SHP2^(-) DT40(RCB1502) Inhibition of antigen-receptor signaling by Platelet Endothelial Cell Adhesion Molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56(lck).
Drosophila HMJ22995  The Crk adapter protein is essential for Drosophila embryogenesis, where it regulates multiple actin-dependent morphogenic events.
C.elegans tm752 The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.
DNA material pX330-FcR gamma gRNA (RDB15903) , pX330-Syk gRNA (RDB15904) , pX330-Hck gRNA (RDB15905) , pX330-Abl gRNA (RDB15906) , pX330-3BP2 gRNA (RDB15907). Syk-dependent tyrosine phosphorylation of 3BP2 is required for optimal FcRγ-mediated phagocytosis and chemokine expression in U937 cells.
Human and Animal Cells PC-14(RCB0446) Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer.
Human and Animal Cells Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.
Human and Animal Cells F-36P(RCB0775) Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase.
Human and Animal Cells F-36E(RCB0776) Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.
DNA material pBluescript-STAM-1 (RDB01792) Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM.
Cellular slime molds Dd-STATb, a Dictyostelium STAT protein with a highly aberrant SH2 domain, functions as a regulator of gene expression during growth and early development.
DNA material pHSG-C3G Human C3G (RDB01595) CrkL activates integrin-mediated hematopoietic cell adhesion through the guanine nucleotide exchange factor C3G.
DNA material pZRmERK2 (RDB01796) CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3.
Pathogenic microorganisms Cortactin is essential for F-actin assembly in enteropathogenic Escherichia coli (EPEC)- and enterohaemorrhagic E. coli (EHEC)-induced pedestals and the alpha-helical region is involved in the localization of cortactin to bacterial attachment sites.