RRC ID |
36920
|
著者 |
Takahashi K, Shiraishi N, Ishiko-Uzuka R, Anada T, Suzuki O, Masumoto H, Sasaki K.
|
タイトル |
Biomechanical evaluation of Ti-Nb-Sn alloy implants with a low Young's modulus.
|
ジャーナル |
Int J Mol Sci
|
Abstract |
Dental implants are widely used and are a predictable treatment in various edentulous cases. Occlusal overload may be causally related to implant bone loss and a loss of integration. Stress concentrations may be diminished using a mechanobiologically integrated implant with bone tissue. The purpose of this study was to investigate the biomechanical behavior, biocompatibility and bioactivity of a Ti-Nb-Sn alloy as a dental implant material. It was compared with cpTi. Cell proliferation and alkaline phosphatase (ALP) activity were quantified. To assess the degree of osseointegration, a push-in test was carried out. Cell proliferation and ALP activity in the cells grown on prepared surfaces were similar for the Ti-Nb-Sn alloy and for cpTi in all the experiments. A comparison between the Ti-Nb-Sn alloy implant and the cpTi implant revealed that no significant difference was apparent for the push-in test values. These results suggest that implants fabricated using Ti-Nb-Sn have a similar biological potential as cpTi and are capable of excellent osseointegration.
|
巻・号 |
16(3)
|
ページ |
5779-88
|
公開日 |
2015-3-12
|
DOI |
10.3390/ijms16035779
|
PII |
ijms16035779
|
PMID |
25775158
|
PMC |
PMC4394505
|
MeSH |
Alloys / chemistry*
Alloys / pharmacology
Animals
Biocompatible Materials / chemistry*
Biocompatible Materials / pharmacology
Cell Line
Cell Proliferation / drug effects
Elastic Modulus
Hydrophobic and Hydrophilic Interactions
Male
Mice
Niobium / chemistry
Prostheses and Implants
Rats
Rats, Sprague-Dawley
Surface Properties
Tin / chemistry
Titanium / chemistry
|
IF |
4.556
|
引用数 |
12
|
WOS 分野
|
CHEMISTRY, MULTIDISCIPLINARY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
ヒト・動物細胞 |
ST2(RCB0224) |