RRC ID 36920
著者 Takahashi K, Shiraishi N, Ishiko-Uzuka R, Anada T, Suzuki O, Masumoto H, Sasaki K.
タイトル Biomechanical evaluation of Ti-Nb-Sn alloy implants with a low Young's modulus.
ジャーナル Int J Mol Sci
Abstract Dental implants are widely used and are a predictable treatment in various edentulous cases. Occlusal overload may be causally related to implant bone loss and a loss of integration. Stress concentrations may be diminished using a mechanobiologically integrated implant with bone tissue. The purpose of this study was to investigate the biomechanical behavior, biocompatibility and bioactivity of a Ti-Nb-Sn alloy as a dental implant material. It was compared with cpTi. Cell proliferation and alkaline phosphatase (ALP) activity were quantified. To assess the degree of osseointegration, a push-in test was carried out. Cell proliferation and ALP activity in the cells grown on prepared surfaces were similar for the Ti-Nb-Sn alloy and for cpTi in all the experiments. A comparison between the Ti-Nb-Sn alloy implant and the cpTi implant revealed that no significant difference was apparent for the push-in test values. These results suggest that implants fabricated using Ti-Nb-Sn have a similar biological potential as cpTi and are capable of excellent osseointegration.
巻・号 16(3)
ページ 5779-88
公開日 2015-3-12
DOI 10.3390/ijms16035779
PII ijms16035779
PMID 25775158
PMC PMC4394505
MeSH Alloys / chemistry* Alloys / pharmacology Animals Biocompatible Materials / chemistry* Biocompatible Materials / pharmacology Cell Line Cell Proliferation / drug effects Elastic Modulus Hydrophobic and Hydrophilic Interactions Male Mice Niobium / chemistry Prostheses and Implants Rats Rats, Sprague-Dawley Surface Properties Tin / chemistry Titanium / chemistry
IF 4.556
引用数 12
WOS 分野 CHEMISTRY, MULTIDISCIPLINARY BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ヒト・動物細胞 ST2(RCB0224)