RRC ID 36926
Author Kishikawa A, Ashour A, Zhu Q, Yasuda M, Ishikawa H, Shimizu K.
Title Multiple Biological Effects of Olive Oil By-products such as Leaves, Stems, Flowers, Olive Milled Waste, Fruit Pulp, and Seeds of the Olive Plant on Skin.
Journal Phytother Res
Abstract As olive oil production increases, so does the amount of olive oil by-products, which can cause environmental problems. Thus, new ways to utilize the by-products are needed. In the present study, five bioactive characteristics of olive oil by-products were assessed, namely their antioxidant, anti-bacterial, anti-melanogenesis, anti-allergic, and collagen-production-promoting activities. First, the extracts of leaves (May and October), stems (May and October), flowers, olive milled waste, fruit pulp and seeds were prepared using two safe solvents, ethanol and water. According to HPLC and LC/MS analysis and Folin-Ciocalteu assay, the ethanol extracts of the leaves (May and October), stems (May and October) and flowers contained oleuropein, and the ethanol extract of the stems showed the highest total phenol content. Oleuropein may contribute to the antioxidant and anti-melanogenesis activities of the leaves, stems, and flowers. However, other active compounds or synergistic effects present in the ethanol extracts are also likely to contribute to the anti-bacterial activity of the leaves and flowers, the anti-melanogenesis activity of some parts, the anti-allergic activity of olive milled waste, and the collagen-production-promoting activity of the leaves, stems, olive milled waste and fruit pulp. This study provides evidence that the by-products of olive oil have the potential to be further developed and used in the skin care industry.
Volume 29(6)
Pages 877-86
Published 2015-6
DOI 10.1002/ptr.5326
PMID 25779104
MeSH Animals Anti-Allergic Agents / chemistry Antioxidants / chemistry Cell Line, Tumor Fibroblasts / drug effects Flowers / chemistry Fruit / chemistry Humans Iridoids / chemistry Melanoma, Experimental Microbial Sensitivity Tests Olea / chemistry* Olive Oil Phenols / chemistry Plant Extracts / chemistry* Plant Leaves / chemistry Plant Oils / chemistry* Rats Seeds / chemistry Skin / cytology Skin / drug effects Solvents
IF 3.766
Times Cited 4
WOS Category PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL
Resource
Human and Animal Cells RBL 2H3(RCB2782)