論文 - 詳細
| RRC ID | 36944 |
|---|---|
| 著者 | Nishizuka S, Tamura G, Maesawa C, Sakata K, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R. |
| タイトル | Analysis of the DPC4 gene in gastric carcinoma. |
| ジャーナル | Jpn J Cancer Res |
| Abstract |
Allelic loss on chromosome 18q is involved in the progression of gastric carcinoma. Recently, DPC4 (deleted in pancreatic carcinoma, locus 4), a candidate tumor suppressor gene, has been localized at 18q21.1. This gene is inactivated in nearly one half of pancreatic carcinomas. We tested for DPC4 gene mutations and allelic status at 18q21 in 30 primary gastric carcinomas and 5 gastric carcinoma cell lines. Polymerase chain reaction single-strand conformation polymorphism and sequencing analyses revealed no DPC4 mutations in any of the primary tumors or cell lines. Homozygous deletion of DPC4 was observed in only 1 (MKN-45) of the 5 (20%) cell lines. This suggests that the target gene for loss on 18q is not DPC4. The true tumor suppressor gene, encoded near DPC4, has yet to be identified. |
| 巻・号 | 88(4) |
| ページ | 335-9 |
| 公開日 | 1997-4-1 |
| DOI | 10.1111/j.1349-7006.1997.tb00385.x |
| PII | S0910505097827263 |
| PMID | 9197522 |
| PMC | PMC5921423 |
| MeSH | Chromosome Deletion Chromosomes, Human, Pair 18 DNA-Binding Proteins* Genes, Tumor Suppressor Humans Pancreatic Neoplasms / genetics Polymorphism, Single-Stranded Conformational Smad4 Protein Stomach Neoplasms / genetics* Trans-Activators / genetics* |
| 引用数 | 16 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HGC-27(RCB0500) MKN1(RCB1003) MKN45(RCB1001) MKN7(RCB0999) MKN74(RCB1002) |