RRC ID 36946
Author Zhang Y, Luo Q, Wang N, Hu F, Jin H, Ge T, Wang C, Qin W.
Title LRG1 suppresses the migration and invasion of hepatocellular carcinoma cells.
Journal Med. Oncol.
Abstract Hepatocellular carcinoma (HCC) is a malignant tumor driven by complex pathological mechanisms and is characterized by fast progression and poor prognosis. The main cause of death in HCC patients is tumor metastasis. However, underlying molecular mechanisms of metastasis are largely unknown in HCC. In the present study, a novel metastasis-related gene, leucine-rich-alpha-2-glycoprotein 1 (LRG1), was identified in HCC. We revealed that LRG1 expression was downregulated in HCC tissues by quantitative real-time PCR and immunohistochemical staining. In vitro assays demonstrated LRG1 had no effect on cell proliferation. Migratory and invasive potential of HCC cells was reduced by ectopic overexpression of LRG1, whereas silencing LRG1 could enhance migration and invasion of HCC cells. Furthermore, exogenous recombinant human protein of LRG1 could inhibit migration and invasion of HCC cells in vitro. The above findings indicate that LGR1 is involved in the inhibition of HCC metastasis and it may function as a novel metastasis suppressor in HCC.
Volume 32(5)
Pages 146
Published 2015-5
DOI 10.1007/s12032-015-0598-7
PMID 25814288
MeSH Adult Aged Carcinoma, Hepatocellular / genetics* Carcinoma, Hepatocellular / pathology* Cell Line, Tumor Cell Movement / genetics* Cell Proliferation / genetics Down-Regulation / genetics Female Gene Expression Regulation, Neoplastic / genetics Glycoproteins / genetics* Hep G2 Cells Humans Liver Neoplasms / genetics* Liver Neoplasms / pathology* Male Middle Aged Neoplasm Invasiveness / genetics* Neoplasm Invasiveness / pathology
IF 2.92
Times Cited 5
Human and Animal Cells HuH-7(RCB1942)