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  • Search Condition : Filter (MeSH = Down-Regulation / genetics)
Species Resource Title
Human and Animal Cells SHP1^(-) DT40(RCB1466) , SHP1^(-)/SHP2^(-) DT40(RCB1501) , SHP2^(-) DT40(RCB1502) , SHIP^(-) DT40(RCB1465) Src homology 2 domain-containing protein-tyrosine phosphatases, SHP-1 and SHP-2, are required for platelet endothelial cell adhesion molecule-1/CD31-mediated inhibitory signaling.
Human and Animal Cells JHOS-2(RCB1521) , JHOS-4(RCB1678) , NIH:OVCAR-3(RCB2135) The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma.
Human and Animal Cells HuH-7(RCB1366) , Li-7(RCB1941) , Hep G2(RCB1648) Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules.
Human and Animal Cells StromaNKtert(RCB2350) The BET bromodomain inhibitor CPI203 overcomes resistance to ABT-199 (venetoclax) by downregulation of BFL-1/A1 in in vitro and in vivo models of MYC+/BCL2+ double hit lymphoma.
Pathogenic bacteria RIMD 2210633 S-nitrosylation-mediated activation of a histidine kinase represses the type 3 secretion system and promotes virulence of an enteric pathogen.
Human and Animal Cells H-1(AES0001) Identification of RNA biomarkers for chemical safety screening in mouse embryonic stem cells using RNA deep sequencing analysis.
Human and Animal Cells PC-9(RCB4455) Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator.
Human and Animal Cells UE7T-13(RCB2161) Cellular Model of Alzheimer's Disease: Aβ1-42 Peptide Induces Amyloid Deposition and a Decrease in Topo Isomerase IIβ and Nurr1 Expression.
Human and Animal Cells RAW 264(RCB0535) CaMKII(δ) regulates osteoclastogenesis through ERK, JNK, and p38 MAPKs and CREB signalling pathway.
Human and Animal Cells MKN45(RCB1001) , MKN74(RCB1002) MiR-129-5p induces cell cycle arrest through modulating HOXC10/Cyclin D1 to inhibit gastric cancer progression.
Human and Animal Cells Huh-7 RNA Editing Modulates Human Hepatic Aryl Hydrocarbon Receptor Expression by Creating MicroRNA Recognition Sequence.
Human and Animal Cells PANC-1(RCB2095) LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer.
Human and Animal Cells ST2(RCB0224) Diabetic osteopenia by decreased β-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene.
Human and Animal Cells 201B7(HPS0063) Suppression of Lefty expression in induced pluripotent cancer cells.
Human and Animal Cells SAS(RCB1974) , HSC-3(RCB1975) , HSC-4(RCB1902) A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions.
Human and Animal Cells A549(RCB0098) CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development.
Clawed frogs / Newts The AP-1 transcription factor JunB functions in Xenopus tail regeneration by positively regulating cell proliferation.
Human and Animal Cells HSC-2(RCB1945) , HSC-3(RCB1975) , HSC-4(RCB1902) , Sa3(RCB0980) , Ca9-22(RCB1976) , HO-1-u-1(RCB2102) , SAS(RCB1974) Tspan15 plays a crucial role in metastasis in oral squamous cell carcinoma.
C.elegans tm1905 , tm1200 , tm1231 Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans.
C.elegans tm1108 Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity.