Reference - Detail
|Author||Nishiwada S, Sho M, Yasuda S, Shimada K, Yamato I, Akahori T, Kinoshita S, Nagai M, Konishi N, Nakajima Y.|
|Title||Clinical significance of CD155 expression in human pancreatic cancer.|
BACKGROUND/AIM:CD155 is expressed in many types of human cells and has diverse functions. We herein evaluated the clinical importance of CD155 in pancreatic cancer.
MATERIALS AND METHODS:We investigated CD155 expression in 134 patients with pancreatic cancer, and evaluated the correlations of CD155 with prognosis, tumor immunity and angiogenesis. Furthermore, CD155 functions were examined.
RESULTS:CD155 expression was abundant in pancreatic cancer tissues. Patients with high CD155 expression had poorer postoperative prognosis than those with low expression. Multivariate analysis indicated that CD155 expression had a significant independent prognostic value. Tumor CD155 expression inversely correlated with the presence of tumor-infiltrating lymphocytes. Furthermore, it significantly positively correlated with vascular endothelial growth factor expression and intra tumoral microvessel density. In addition, silencing of CD155 inhibited proliferation, and induced cell-cycle arrest at G2/M phase in pancreatic cancer cells.
CONCLUSION:CD155 may play a critical role through both immunological and non-immuno logical mechanisms in pancreatic cancer and may be a therapeutic target for this intractable malignancy.
|MeSH||Aged Biomarkers, Tumor / biosynthesis* Biomarkers, Tumor / immunology Female Gene Expression Regulation, Neoplastic Humans Male Middle Aged Neoplasm Staging Neovascularization, Pathologic / genetics* Neovascularization, Pathologic / pathology Pancreatic Neoplasms / genetics* Pancreatic Neoplasms / immunology Pancreatic Neoplasms / pathology Prognosis Receptors, Virus / biosynthesis* Receptors, Virus / genetics Receptors, Virus / immunology Vascular Endothelial Growth Factor A / genetics|
|Human and Animal Cells||MIA Paca2(RCB2094) PANC-1(RCB2095)|